Rh(I)-catalyzed regio- and enantioselective allylic alkylation of Meldrum's acid
Rh(I)-catalyzed regio- and enantioselective allylic alkylation of Meldrum's acid
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DOI：
10.1016/j.cclet.2020.04.009
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发表时间：
2021-02-12
影响因子：
9.1
通讯作者：
Li，Changkun
中科院分区：
文献类型：
--
作者：
Liu，Min;Zhao，Haiying;Li，Changkun
开发了一种 Rh(I) 催化的 Meldrum 酸与带有烷基的外消旋烯丙基底物的高度区域和对映选择性烯丙基烷基化反应。手性双恶唑啉膦配体的应用对于高产率和选择性至关重要。该方法提供了快速获得各种手性β-烷基-γ,δ-不饱和羧酸及其衍生物的方法。
A Rh(I)-catalyzed highly regio- and enantioselective allylic alkylation of Meldrum acid with racemic allylic substrates bearing alkyl groups has been developed. The applying of chiral bisoxazopinephosphine ligand is essential for the high yields and selectivities. This method provides a rapid access to various chiralβ-alkyl-γ,δ-unsaturated carboxylic acids and their derivatives.