Mediating Tumor Targeting Efficiency of Nanoparticles Through Design
Mediating Tumor Targeting Efficiency of Nanoparticles Through Design
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DOI：
10.1021/nl900031y
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发表时间：
2009-05-01
期刊：
影响因子：
10.8
通讯作者：
Chan, Warren C. W.
中科院分区：
文献类型：
--
作者：
Perrault, Steven D.;Walkey, Carl;Chan, Warren C. W.
在这里，我们系统地研究了纳米颗粒尺寸（10-100 nm）和表面化学（即，聚（乙二醇））对体内肿瘤被动靶向的影响。我们发现纳米颗粒的物理和化学性质影响其药代动力学行为，最终决定了其肿瘤蓄积能力。有趣的是，纳米颗粒在肿瘤内的渗透高度依赖于纳米颗粒的总体尺寸，其中较大的纳米颗粒似乎停留在脉管系统附近，而较小的纳米颗粒迅速扩散到整个肿瘤基质中。我们的研究结果提供了设计参数的工程纳米粒子优化肿瘤靶向造影剂和治疗。
Here we systematically examined the effect of nanoparticle size (10-100 nm) and surface chemistry (i.e., poly(ethylene glycol)) on passive targeting of tumors in vivo. We found that the physical and chemical properties of the nanoparticles influenced their pharmacokinetic behavior, which ultimately determined their tumor accumulation capacity. Interestingly, the permeation of nanoparticles within the tumor is highly dependent on the overall size of the nanoparticle, where larger nanoparticles appear to stay near the vasculature while smaller nanoparticles rapidly diffuse throughout the tumor matrix. Our results provide design parameters for engineering nanoparticles for optimized tumor targeting of contrast agents and therapeutics.