RNA matchmaking in chromatin regulation.
RNA matchmaking in chromatin regulation.
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DOI：
10.1042/bst20191225
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发表时间：
2020-12-18
影响因子：
3.9
通讯作者：
Johnson AM
中科院分区：
文献类型：
--
作者：
Wu SK;Roberts JT;Balas MM;Johnson AM
除了作为基因表达的产物，RNA还可以影响染色质的调节。人类基因组的大部分都具有转录能力，并且RNA聚合酶II产生的大部分非蛋白质编码转录物富集在细胞核中。许多染色质调节因子可以与细胞核中的这些ncRNA结合;在某些情况下，存在源于这些相互作用的直接RNA介导的染色质调节机制的明确例子，而其他一些尚未确定。最近的研究强调了通过RNA匹配进行染色质调节的例子，我们在这里广泛使用这个术语来描述一个RNA分子与RNA或DNA匹配之间的分子间碱基配对相互作用。这篇综述提供了RNA匹配的例子，调节染色质过程，并总结了用于捕获这些事件的技术方法。
Beyond being the product of gene expression, RNA can also influence the regulation of chromatin. The majority of the human genome has the capacity to be transcribed and the majority of the non-protein-coding transcripts made by RNA Polymerase II are enriched in the nucleus. Many chromatin regulators can bind to these ncRNAs in the nucleus; in some cases there are clear examples of direct RNA-mediated chromatin regulation mechanisms stemming from these interactions, while others have yet to be determined. Recent studies have highlighted examples of chromatin regulation via RNA matchmaking, a term we use broadly here to describe intermolecular base-pairing interactions between one RNA molecule and an RNA or DNA match. This review provides examples of RNA matchmaking that regulates chromatin processes and summarizes the technical approaches used to capture these events.