Workflow for Managing Impurities in an Integrated Crystallization Process
Workflow for Managing Impurities in an Integrated Crystallization Process
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DOI：
10.1002/aic.12027
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发表时间：
2010-03-01
期刊：
影响因子：
3.7
通讯作者：
Wibowo, Christianto
中科院分区：
文献类型：
--
作者：
Cheng, Yuen S.;Lam, Ka W.;Wibowo, Christianto
提出了一种由实验、建模和综合组成的工作流程，以管理结晶过程中产品晶体中的杂质含量，并考虑了整个结晶过程和下游加工步骤。固液平衡、杂质夹杂、洗涤和脱液实验的设计使得实验数据或由这些数据得出的模型参数可以很容易地用于工艺设计。讨论了实验设计的指导原则和过程综合中的权衡。以维生素C(抗坏血酸)的提纯为例说明了工作流程。(C)2009年美国化学工程师学会学报，56：633-649,2010
A workflow consisting of experiments, modeling, and synthesis is presented for man aging the impurity content in the product crystals of a crystallization process taking into consideration the entire train of crystallization and downstream processing steps. Experiments on solid-liquid equilibrium, impurity inclusion, washing, and deliquoring are designed in such a way that the experimental data or the model parameters derived from these data can be readily used for process design. Guidelines for experimental design and, tradeoffs in process synthesis are discussed. The workflow is illustrated using the purification of Vitamin C (ascorbic acid) as a case study. (C) 2009 American Institute of Chemical Engineers AIChE J, 56: 633-649, 2010