Diffuse interstitial fibrosis in nonasbestos pneumoconiosis--a pathological study.
Diffuse interstitial fibrosis in nonasbestos pneumoconiosis--a pathological study.
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非石棉尘肺弥漫性间质纤维化——病理学研究。
DOI：
10.1159/000196185
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Keizo Chiyotani
中科院分区：
文献类型：
--
作者：
Koichi Honma;Keizo Chiyotani
233例非石棉尘肺尸检病理检查发现64例（27.5%）弥漫性间质纤维化（DIF），其中45例（19.3%）为双侧受累，9例（3.9%）为广泛性间质性肺炎。与无DIF的患者相比，DIF患者的年龄明显更大，职业史更长。DIF的发生与基础疾病（矽肺或混合性粉尘尘肺）的类型之间没有相关性，但广泛的DIF更常见于混合性粉尘尘肺。广泛DIF发展为原位恶性肿瘤的频率（33.3%）远高于局灶性疾病（2.6%）。
Pathological examinations of 233 consecutive autopsy cases with nonasbestos pneumonconiosis revealed evidence of diffuse interstitial fibrosis (DIF) in 64 (27.5%), among whom 45 (19.3%) showed bilateral involvement and 9 (3.9%) extensive disease closely resembling usual interstitial pneumonia. The patients with DIF were significantly older and had longer occupational histories as compared with those without DIF. There was no correlation between the occurrence of DIF and the type of the underlying disease (silicosis or mixed dust pneumoconiosis) except that an extensive DIF was more frequently associated with mixed dust pneumoconiosis. The extensive DIF developed an in situ malignancy much more frequently (33.3%) than the focal disease (2.6%).