Industrial production of amino acids by coryneform bacteria
Industrial production of amino acids by coryneform bacteria
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DOI：
10.1016/s0168-1656(03)00149-4
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发表时间：
2003-09-04
影响因子：
4.1
通讯作者：
Hermann, T
中科院分区：
文献类型：
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作者：
Hermann, T
在20世纪50年代，谷氨酸棒杆菌被发现是一种非常有效的L-谷氨酸的生产者。从那时起，从吨位和经济价值的角度来看，使用棒状杆菌属细菌的生物技术工艺发展成为最重要的工艺之一。L谷氨酸和L赖氨酸是目前的大宗产品。棒状杆菌产生的其他氨基酸包括L-缬氨酸、L-异亮氨酸、L-苏氨酸、L-天冬氨酸和L-丙氨酸。应用范围从饲料到食品和药品。棒状杆菌生产的氨基酸的市场不断增长，导致了生物工艺和下游技术以及分子生物学方面的重大改进。在过去的十年里，为提高生产率和降低生产成本做出了很大努力。本文综述了棒状杆菌生产的氨基酸的世界市场。总结了生物处理技术的重大改进，即重复补料间歇生产或连续生产。通过应用更复杂的投料和自动化策略，生物处理技术本身得到了进一步改进。尽管在过去十年中有几种氨基酸朝着商品化的方向发展，但生产过程中的其他方面，如无菌或污染物检测，仍然具有越来越大的相关性。最后，这项审查的一个重点是下游技术的最新发展。(C)2003爱思唯尔B.V.保留所有权利。
In the 1950s Corynebacterium glutamicum was found to be a very efficient producer Of L-glutamic acid. Since this time biotechnological processes with bacteria of the species Corynebacterium developed to be among the most important in terms of tonnage and economical value. L-Glutamic acid and L-lysine are bulk products nowadays. L-Valine, L-isoleucine, L-threonine, L-aspartic acid and L-alanine are among other amino acids produced by Corynebacteria. Applications range from feed to food and pharmaceutical products. The growing market for amino acids produced with Corynebacteria led to significant improvements in bioprocess and downstream technology as well as in molecular biology. During the last decade big efforts were made to increase the productivity and to decrease the production costs. This review gives an overview of the world market for amino acids produced by Corynebacteria. Significant improvements in bioprocess technology, i.e. repeated fed batch or continuous production are summarised. Bioprocess technology itself was improved furthermore by application of more sophisticated feeding and automatisation strategies. Even though several amino acids developed towards commodities in the last decade, side aspects of the production process like sterility or detection of contaminants still have increasing relevance. Finally one focus of this review is on recent developments in downstream technology. (C) 2003 Elsevier B.V. All rights reserved.