Adipose-derived stem cells: current findings and future perspectives.
Adipose-derived stem cells: current findings and future perspectives.
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DOI：
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发表时间：
2011-02
影响因子：
1.4
通讯作者：
Morikuni Tobita;Hakan Orbay;H. Mizuno
中科院分区：
文献类型：
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作者：
Morikuni Tobita;Hakan Orbay;H. Mizuno
脂肪组织是间充质干细胞的丰富来源，其在再生医学领域已显示出前景。此外，这些细胞可以容易地大量收获，供体部位发病率低。在过去的十年中，许多研究提供了关于脂肪干细胞安全性和有效性的临床前数据，支持这些细胞在未来临床应用中的使用。各种临床试验已表明脂肪源性干细胞在整形外科、骨科手术、口腔颌面外科和心脏外科等医学领域的亚专业中具有再生能力。此外，大量的知识有关的收获，表征和培养的脂肪来源的干细胞已被报道。本文将总结有关脂肪干细胞在再生医学中应用的体外研究、临床前动物模型和近期临床试验的数据。
Adipose tissue is an abundant source of mesenchymal stem cells, which have shown promise in the field of regenerative medicine. Furthermore, these cells can be readily harvested in large numbers with low donor-site morbidity. During the past decade, numerous studies have provided preclinical data on the safety and efficacy of adipose-derived stem cells, supporting the use of these cells in future clinical applications. Various clinical trials have shown the regenerative capability of adipose-derived stem cells in subspecialties of medical fields such as plastic surgery, orthopedic surgery, oral and maxillofacial surgery, and cardiac surgery. In addition, a great deal of knowledge concerning the harvesting, characterization, and culture of adipose-derived stem cells has been reported. This review will summarize data from in vitro studies, pre-clinical animal models, and recent clinical trials concerning the use of adipose-derived stem cells in regenerative medicine.