Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study
Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study
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DOI：
10.1016/j.bone.2007.09.056
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发表时间：
2008-02-01
期刊：
影响因子：
4.1
通讯作者：
Yamamoto, Masaharu
中科院分区：
文献类型：
--
作者：
Nakamura, Kazutoshi;Tsugawa, Naoko;Yamamoto, Masaharu
关于亚洲妇女维生素D状况与骨骼健康的关系，人们知之甚少。本研究的目的是确定血清25-羟基维生素D（25[OH]D）浓度与骨量和骨代谢的关系。这项横断面的、以社区为基础的流行病学研究在600名门诊绝经后妇女中进行。放射免疫法测定血清25（OH）D浓度。其他血液生化指标包括全段甲状旁腺激素和骨转换标志物，包括骨钙素和I型胶原交联N端肽。采用QDR 4500 a型双能X线骨密度仪测量腰椎和右侧股骨颈的骨密度。平均血清25（OH）D浓度为55.6 nmol/L（SD 14.6）。血清25（OH）D浓度与股骨颈BMD呈线性相关（R-2=0.020，P=0.003），但与腰椎BMD无相关性。低BMD（定义为t评分= 70 nmol/L）的比值比（OR）。与参考组（>= 70 nmol/L）相比，30- 40-nmol/L（调整后OR=3.6，95% CI：1.1-12.1）和40- 50-nmol/L（调整后OR=7.6，95% CI：2.5-23.2）组股骨颈低BMD的患病率显著较高。与血清25（OH）D >= 50 nmol/L的受试者相比，血清25（OH）D < 50 nmol/L的受试者的完整PTH平均血清浓度显著较高。本研究表明，较高的血清25（OH）D浓度与股骨颈BMD增加相关，并且需要至少70 nmol/L的血清25（OH）D浓度来获得股骨颈的高BMD，并且需要至少50 nmol/L的血清25（OH）D浓度来实现正常PTH水平并防止居家绝经后日本妇女的低BMD。(c)2007爱思唯尔公司All rights reserved.
Little has been understood about vitamin D status in relation to bone health in Asian women. The purpose of this study was to identify how the serum 25-hydroxyvitamin D (25[OH]D) concentration is associated with bone mass and bone metabolism. This cross-sectional, community-based epidemiologic study was conducted among 600 ambulatory postmenopausal women. The serum 25(OH)D concentration was measured with radioimmunoassay. Other blood biochemical measurements were intact parathyroid hormone and markers of bone turnover, including osteocalcin and type I collagen cross-linked N-telopeptides. Bone mineral density (BMD) of the lumbar spine and right femoral neck were measured with the dual-energy X-ray absorptiometry method using a QDR4500a. The mean serum 25(OH)D concentration was 55.6 nmol/L (SD 14.6). Serum 25(OH)D concentration was linearly associated with BMD of the femoral neck (R-2=0.020, P=0.003), but not with BMD of the lumbar spine. Odds ratios (ORs) for low BMD (defined as t score = 70 nmol/L). Prevalence of low BMD for the femoral neck was significantly higher in the 30- to 40-nmol/L (adjusted OR=3.6, 95% CI: 1.1-12.1) and the 40- to 50-nmol/L (adjusted OR=7.6, 95% CI: 2.5-23.2) groups compared to the reference group (>= 70 nmol/L). The mean serum concentration of intact PTH was significantly higher in subjects with serum 25(OH)D < 50 nmol/L compared to those with serum 25(OH)D >= 50 nmol/L. The present study suggests that higher serum 25(OH)D concentrations are associated with increased BMD of the femoral neck, and that a serum 25(OH)D concentration of at least 70 nmol/L is needed to obtain high BMD of the femoral neck, and that of at least 50 nmol/L is needed to achieve normal PTH levels and prevent low BMD in home-dwelling postmenopausal Japanese women. (c) 2007 Elsevier Inc. All rights reserved.