Clinical implementation of x-ray phase-contrast imaging: Theoretical foundations and design considerations
Clinical implementation of x-ray phase-contrast imaging: Theoretical foundations and design considerations
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DOI：
10.1118/1.1593836
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发表时间：
2003-08-01
期刊：
影响因子：
3.8
通讯作者：
Liu, H
中科院分区：
文献类型：
--
作者：
Wu, XZ;Liu, H
本文介绍了一种临床可行的X射线相位衬度成像技术的理论基础和设计考虑。与文献中对弱吸收相位物体成像的分析不同，本文提出了一种新的同轴相位衬度成像的形式，分析了临床上四个重要因素对相位衬度的影响。这些是身体部位衰减、来自有限尺寸焦点的球面波的空间相干性、以及多色X射线和用于临床应用的患者辐射剂量。本文提出的理论可广泛应用于诊断X射线成像程序。作为一个例子，进行计算机模拟，并得出最佳的设计参数，用于临床乳腺摄影。最后给出了体模实验结果，验证了理论分析和计算机模拟的正确性。(C)2003年美国医学物理学家协会。
Theoretical foundation and design considerations of a clinical feasible x-ray phase contrast imaging technique were presented in this paper. Different from the analysis of imaging phase object with weak absorption in literature, we proposed a new formalism for in-line phase-contrast imaging to analyze the effects of four clinically important factors on the phase contrast. These are the body parts attenuation, the spatial coherence of spherical waves from a finite-size focal spot, and polychromatic x-ray and radiation doses to patients for clinical applications. The theory presented in this paper can be applied widely in diagnostic x-ray imaging procedures. As an example, computer simulations were conducted and optimal design parameters were derived for clinical mammography. The results of phantom experiments were also presented which validated the theoretical analysis and computer simulations. (C) 2003 American Association of Physicists in Medicine.