MicroRNA-21 gene and cancer
MicroRNA-21 gene and cancer
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DOI：
10.1007/s12032-012-0376-8
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发表时间：
2013-03-01
期刊：
影响因子：
3.4
通讯作者：
Cheng, Xiang Chao
中科院分区：
文献类型：
--
作者：
Huang, Yong;Yang, You Bing;Cheng, Xiang Chao
MicroRNA（miRNAs）是一类由18-27个核苷酸组成的单链RNA分子，在转录后水平调控基因表达。研究表明，miRNAs参与调控多种生理功能，包括发育、细胞分化、增殖和凋亡。越来越多的证据表明，miRNAs通过调节其靶基因相关的信号通路，影响肿瘤的发生发展，发挥抑癌或致癌作用。miRNA-21是人类细胞中最早发现的miRNA之一，在不同类型的实体瘤中表达显著上调。它的异常表达水平与肿瘤的发病机制密切相关。本文就miRNA-21及其与肿瘤关系的研究进展作一综述。
MicroRNAs (miRNAs) are a class of 18-27-nucleotides single-stranded RNA molecules that regulate gene expression at the post-transcriptional level. It has been demonstrated that miRNAs regulate a variety of physiological functions, including development, cell differentiation, proliferation, and apoptosis. There are growing evidence showed that miRNAs can affect the genesis and development of tumor and play a kind of tumor suppressor or oncogenic function by regulating its targetted gene-related signal pathway. miRNA-21 is one of the early discovered miRNAs in human cells, and the expression of miRNA-21 is significantly upregulated in different kinds of solid tumors. Its abnormal expression levels are closely associated with pathogenesis of cancers. This review summarizes the recent study on the field of miRNA-21 and its association with cancer.