THE INTERACTION OF AGING AND ENDURANCE EXERCISE UPON THE MITOCHONDRIAL-FUNCTION OF SKELETAL-MUSCLE
THE INTERACTION OF AGING AND ENDURANCE EXERCISE UPON THE MITOCHONDRIAL-FUNCTION OF SKELETAL-MUSCLE
复制标题
DOI：
10.1093/geronj/36.6.642
复制
发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
ARDIES, CM
中科院分区：
文献类型：
--
作者：
FARRAR, RP;MARTIN, TP;ARDIES, CM
在150、300和720日龄的安静对照大鼠和300和720日龄的训练大鼠中测定线粒体功能。线粒体分离自腓肠肌-跖肌细胞的肌膜下和肌原纤维间两个区域。状态3呼吸并没有随着年龄的增长而变化，在对照组动物，但耐力训练增强状态3呼吸在300和720天的训练动物。年龄降低了肌原纤维间线粒体蛋白的数量，而训练增加了细胞两个区域的线粒体蛋白。骨骼肌中氧化代谢的减少是由于线粒体蛋白的减少，而不是线粒体功能的减少。
Mitochondrial function was determined in sedentary-control rats, 150, 300 and 720 days of age, and in endurance-trained rats 300 and 720 days of age. The mitochondria were isolated from 2 regions of the cell of the gastrocnemius-plantaris muscle, subsarcolemmal and intermyofibrillar. State 3 respiration did not change with increasing age in control animals, but endurance training enhanced state 3 respiration in both the 300- and 720-day-old trained animals. Age decreased the amount of intermyofibrillar mitochondrial protein, while training increased the mitochondrial protein of both regions of the cell. The decrease in oxidative metabolism in the skeletal muscle resulted from a decrease in mitochondrial protein, not to a decrease in mitochondrial function.