Androgen receptor, Ki67, and p53 expression in radical prostatectomy specimens predict treatment failure in Japanese population
Androgen receptor, Ki67, and p53 expression in radical prostatectomy specimens predict treatment failure in Japanese population
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DOI：
10.1016/j.urology.2005.02.028
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发表时间：
2005-08-01
期刊：
影响因子：
2.1
通讯作者：
Ogawa, O
中科院分区：
文献类型：
--
作者：
Inoue, T;Segawa, T;Ogawa, O
目标。使用日本患者的组织微阵列评估局限性前列腺癌的多种已知预后标志物。分子研究表明种族影响前列腺肿瘤生物学。方法。对 52 名患者的标本进行了研究，这些患者于 1997 年至 2001 年间在我们的机构接受了根治性手术，没有接受新辅助激素治疗，并且具有三个或更多可用且完整的癌点。检查了 Ki67、p53 和雄激素受体抗原的表达。将免疫组织化学评分与使用前列腺特异性抗原监测的化学复发结果进行比较。结果。肿瘤病理分类（P = 0.047）、世界卫生组织评分（P = 0.026）、世界卫生组织组织学分级（P = 0.026）和手术切缘状态（P = 0.018）是预测生化失败的重要常规临床病理变量。组织微阵列格里森总和（P = 0.038）、组织微阵列初级格里森分级（P = 0.013）、Ki67标记指数（P
Objectives. To evaluate multiple known prognostic markers in localized prostate cancer using tissue microarrays in Japanese patients. Molecular studies have suggested that ethnicity influences prostate tumor biology.Methods. Specimens were studied from 52 patients who underwent radical surgery at our institution between 1997 and 2001 without neoadjuvant hormonal therapy and with three or more available and complete cancer spots. Ki67, p53, and androgen receptor antigen expression were examined. Immunohistochemical scores were compared with outcomes of chemical relapse as monitored using prostate-specific antigen.Results. Pathologic tumor classification (P = 0.047), World Health Organization score (P = 0.026), World Health Organization histologic grade (P = 0.026), and surgical margin status (P = 0.018) were significant conventional clinicopathologic variables for predicting biochemical failure. The tissue microarray Gleason sum (P = 0.038), tissue microarray primary Gleason grade (P = 0.013), Ki67 labeling index (P