LanDis: the disease landscape explorer
LanDis: the disease landscape explorer
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DOI：
10.1038/s41431-023-01511-9
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发表时间：
2024-01-10
影响因子：
5.2
通讯作者：
Paccanaro，Alberto
中科院分区：
文献类型：
--
作者：
Caniza，Horacio;Caceres，Juan J.;Paccanaro，Alberto
从网络医学的角度来看，疾病是相互作用组扰动的结果。这些扰动往往出现在相互作用组的特定邻域，即疾病模块，而与表型相似疾病相关的模块往往位于附近区域。我们介绍了LanDis，一个免费提供的基于网络的交互式工具（https：//paccanarolab.org/landis），它允许领域专家，医生和更大的科学界以图形方式导航超过4400万对遗传性疾病的模块之间的相互作用组距离。类似地图的界面提供了疾病对之间的详细比较以及支持证据。LanDis中的每一种疾病都与OMIM和UniProt中的相关条目相关联，为深入分析提供了起点，并为深入了解疾病的病因和鉴别诊断提供了机会。
From a network medicine perspective, a disease is the consequence of perturbations on the interactome. These perturbations tend to appear in a specific neighbourhood on the interactome, the disease module, and modules related to phenotypically similar diseases tend to be located in close-by regions. We present LanDis, a freely available web-based interactive tool (https://paccanarolab.org/landis) that allows domain experts, medical doctors and the larger scientific community to graphically navigate the interactome distances between the modules of over 44 million pairs of heritable diseases. The map-like interface provides detailed comparisons between pairs of diseases together with supporting evidence. Every disease in LanDis is linked to relevant entries in OMIM and UniProt, providing a starting point for in-depth analysis and an opportunity for novel insight into the aetiology of diseases as well as differential diagnosis.