OUTCOME OF TREATMENT FOR CHILDHOOD-CANCER IN BLACK AS COMPARED WITH WHITE-CHILDREN - THE ST-JUDE-CHILDRENS-RESEARCH-HOSPITAL EXPERIENCE, 1962 THROUGH 1992
OUTCOME OF TREATMENT FOR CHILDHOOD-CANCER IN BLACK AS COMPARED WITH WHITE-CHILDREN - THE ST-JUDE-CHILDRENS-RESEARCH-HOSPITAL EXPERIENCE, 1962 THROUGH 1992
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DOI：
10.1001/jama.273.8.633
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发表时间：
1995-02-22
影响因子：
120.7
通讯作者：
CRIST, WM
中科院分区：
文献类型：
--
作者：
PUI, CH;BOYETT, JM;CRIST, WM
客观。-为了确定是否有一个儿童癌症预后的种族差异。设计。按种族进行总体（30年）生存分析，随后进行“早期"和”近期"治疗时期的单独研究，定义为特定肿瘤类型显示显著改善结局的时间点，进行分层分析以调整公认的预后特征。儿科肿瘤研究和治疗中心。病人。-该研究包括798名黑人和4507名白色儿童，他们在1962年1月至1992年6月期间接受了新诊断的恶性肿瘤治疗。这些患者被接受治疗，无论其经济状况如何，并参加了疾病特异性方案。在30年的研究期间，黑人儿童的生存率明显低于白色儿童（P
Objective.-To determine whether there is a racial difference in prognosis among childhood cancers.Design.-An overall (30-year) survival analysis by race was followed by separate studies for ''early'' and ''recent'' treatment eras, defined by time points at which significantly improved outcome was demonstrated for specific tumor types, Stratified analyses were performed to adjust for recognized prognostic features.Setting.-Pediatric oncology research and treatment center.Patients.-The study included 798 black and 4507 white children with newly diagnosed malignancies treated from January 1962 through June 1992. These patients were accepted for treatment regardless of their financial status and were enrolled on disease-specific protocols.Results.-Across the 30-year study period, black children had a significantly poorer rate of survival than white children (P