Emerging Applications of Mass Spectrometry-Based Metabolic Fingerprinting in Clinics
Emerging Applications of Mass Spectrometry-Based Metabolic Fingerprinting in Clinics
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DOI：
10.1002/aisy.202100191
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发表时间：
2022-01-23
影响因子：
7.4
通讯作者：
Qian, Kun
中科院分区：
文献类型：
--
作者：
Cao, Jing;Wang, Yuning;Qian, Kun
最近开发的一些基于MS的代谢指纹分析正在推动代谢分析系统进入实际的临床应用，包括但不限于疾病诊断。本文综述了基于质谱学的代谢指纹图谱分析方法学的最新研究进展和临床应用。这些发展解决了基于MS的代谢指纹分析系统的实际临床应用方面的挑战，例如快速信号读出、高通量和直接MS分析以及复杂生物样本的智能数据挖掘。
A number of recently developed mass spectrometry (MS)-based metabolic fingerprinting analyses are promoting metabolic analysis systems into practical clinical applications, including but not limited to disease diagnosis. Herein, recent cutting-edge research on mass spectrometry-based metabolic fingerprinting analytical methodology and clinical applications are described. These developments resolve challenges regarding the practical clinical applications of MS-based metabolic fingerprinting analysis systems, such as rapid signal readout, high throughput and direct MS analysis, and intelligent data mining of complex biological samples.