TRPM2 Ca2+ permeable cation channels:: from gene to biological function
TRPM2 Ca2+ permeable cation channels:: from gene to biological function
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DOI：
10.1016/s0143-4160(03)00057-5
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发表时间：
2003-05-01
期刊：
影响因子：
4
通讯作者：
Scharenberg, AM
中科院分区：
文献类型：
--
作者：
Perraud, AL;Schmitz, C;Scharenberg, AM
TRPM 2是最近鉴定的TRPM家族阳离子通道，其在已知离子通道中是独特的，因为其含有与NUDT 9 ADP-核糖水解酶同源的C-末端结构域，并且具有固有的ADP-核糖水解酶活性。在这里，TRPM2基因，转录本，预测的蛋白质产物，和组装的多聚体通道的可用信息进行了全面的审查和合成，以突出未来工作的重要领域，并提供洞察TRPM2通道的潜在生物学功能。(C)2003爱思唯尔科技有限公司版权所有。
TRPM2 is a recently identified TRPM family cation channel which is unique among known ion channels in that it contains a C-terminal domain which is homologous to the NUDT9 ADP-ribose hydrolase and possesses intrinsic ADP-ribose hydrolase activity. Here, available information on the TRPM2 gene, transcripts, predicted protein products, and assembled multimeric channels is comprehensively reviewed and synthesized to highlight important areas for future work and provide insight into potential biological function(s) of TRPM2 channels. (C) 2003 Elsevier Science Ltd. All rights reserved.