The synthesis of curved and linear structures from a minimal set of monomers.
The synthesis of curved and linear structures from a minimal set of monomers.
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DOI：
10.1021/jo051639u
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发表时间：
2005-10
期刊：
影响因子：
--
通讯作者：
Christopher G. Levins;C. Schafmeister
中科院分区：
文献类型：
--
作者：
Christopher G. Levins;C. Schafmeister
[反应：见正文]由一组两种对映体双氨基酸单体组装设计形状的螺梯低聚物。合成了两种不同单体序列的四聚体，研究了单体立体化学对大分子形状的影响。二维NMR实验被用来确定的低聚物的上下文中的单体的构象偏好。这个结构研究的结果被用来设计两个五聚体：一个类似于杆，另一个具有弯曲的形状。五聚体用萘基和丹磺酰基末端标记。通过测量萘基和丹磺酰基荧光团对之间的荧光共振能量转移效率证实了设计假设。
[reaction: see text] Spiro-ladder oligomers of designed shape were assembled from a set of two enantiomeric bis-amino acid monomers. Two tetramers of differing monomer sequence were synthesized to study the effect of monomer stereochemistry upon macromolecular shape. Two-dimensional NMR experiments were used to determine the conformational preference of the monomers within the context of the oligomers. The results of this structural study were used to design two pentamers: one resembling a rod and another with a curved shape. The pentamers were end-labeled with naphthyl and dansyl groups. The design hypothesis was confirmed by measuring the efficiency of fluorescence resonance energy transfer between the naphthyl and dansyl fluorophore pair.