Urinary excretion kinetics of methylamphetamine in man
Urinary excretion kinetics of methylamphetamine in man
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人体内甲基苯丙胺的尿排泄动力学
DOI：
10.1111/j.2042-7158.1965.tb07757.x
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发表时间：
1965
影响因子：
3.3
通讯作者：
M. Rowland
中科院分区：
文献类型：
--
作者：
A. Beckett;M. Rowland
对三名男性受试者口服 (+)- 和 (-)- 甲基苯丙胺盐酸盐后，研究了甲基苯丙胺及其代谢物苯丙胺的尿排泄。两种胺的排泄率均发生波动，且与尿 pH 值的变化相关。当尿液分别通过氯化铵和碳酸氢钠维持酸性或碱性时，波动就会消失。碱性尿液条件下两种胺的排泄总量低于酸性尿液条件。甲基苯丙胺的 N-去甲基化程度较小，但 (+)- 异构体的 N-去甲基化程度高于 (-)- 异构体。
The urinary excretion of methylamphetamine and its metabolite, amphetamine, was studied after oral administration of (+)‐ and (–)‐methylamphetamine hydrochloride to three male subjects. Fluctuations in the excretion rate of both amines occurred and were associated with changes in urinary pH. The fluctuations were abolished when the urine was maintained either acid or alkaline, by administration of ammonium chloride and sodium bicarbonate respectively. The total amount of both amines excreted was lower under alkaline than acid urine conditions. N‐Demethylation of methylamphetamine was small, but greater for the (+)‐ than the (–)‐isomer.