The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.
The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.
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自体肽-主要组织相容性复合体（MHC）识别的强度决定naïve CD8+ T细胞的稳态，但其对外来抗原反应性的影响是有争议的。由于CD5表达与自我识别相关，我们研究了CD5lo和CD5hi naïve CD8+ T细胞。基因表达特征表明，与CD5lo细胞相比，CD5hi细胞具有更好的反应性和分化能力，我们发现CD5hi细胞库在识别外来抗原过程中表现出更有效的克隆招募和扩增，以及对炎症线索的反应性增强。然而，外源肽- mhc识别在两个亚群中是相似的。因此，具有较高自身反应性的CD8+ T细胞主导了对外来抗原的免疫反应，这意味着T细胞库多样性和自身免疫。
The strength of self-peptide–major histocompatibility complex (MHC) recognition dictates naïve CD8+ T cell homeostasis, but its effect on foreign antigen reactivity is controversial. As CD5 expression correlates with self-recognition, we studied CD5lo and CD5hi naïve CD8+ T cells. Gene expression characteristics suggested CD5hi cells were better poised for reactivity and differentiation compared to the CD5lo population, and we found that the CD5hi pool exhibited more efficient clonal recruitment and expansion, as well as enhanced reactivity to inflammatory cues, during recognition of foreign antigen. Yet foreign peptide–MHC recognition was similar for both subsets. Thus, CD8+ T cells with higher self-reactivity dominate the immune response against foreign antigens, with implications for T cell repertoire diversity and autoimmunity.