Motor alterations associated with exposure to manganese in the environment in Mexico
Motor alterations associated with exposure to manganese in the environment in Mexico
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DOI：
10.1016/j.scitotenv.2006.03.025
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发表时间：
2006-09-15
影响因子：
9.8
通讯作者：
Santos-Burgoa, Carlos
中科院分区：
文献类型：
--
作者：
Rodriguez-Agudelo, Yaneth;Riojas-Rodriguez, Horacio;Santos-Burgoa, Carlos
过量摄入锰（Mn）会导致神经毒性（帕金森样综合征）或精神损害（锰疯狂）。几项研究表明，运动和神经行为的改变与工作场所暴露于锰有关。然而，关于整个人群的环境暴露影响的研究很少。我们研究了生活在墨西哥矿区的人的运动改变的风险。我们研究了288个人（168名妇女和120名男子）从8个社区在不同的距离锰提取或加工设施在莫兰戈区。我们测量了空气中的颗粒物，水，土壤和作物中的锰浓度，并评估了锰暴露的可能途径。我们还采取了人的血液样本，并确定其浓度的锰和铅（铅）。我们使用“神经精神病学诊断量表”Ardila和Ostrosky-Solis的神经心理成套测验来评估运动功能。饮用水和玉米籽粒中锰的浓度在大多数采样点低于检出限。土壤中DTPA提取的锰含量范围为6至280 mg kg（-1），在接近锰提取或加工设施的地方，平均值最大。空气锰浓度范围在0.003和5.86 μ g/m3之间;平均值为0.42 μ g/m3，中位数为0.10 μ g/m3，平均值（几何平均值）为0.13 μ g/m3。平均血锰浓度为10.16 μ g/l，几何平均值为9.44 μ g/l，范围为5.0 - 31.0 μ g/l。我们发现血液中锰浓度与运动试验之间没有关联。空气中锰浓度与评估两种运动协调性（OR 3.69; 95% CI 0.9，15.13）和手部运动位置变化（OR 3.09; CI 95% 1.07，8.92）的运动试验之间存在统计学显著相关性。还发现了与评价冲突反应（探索运动的口头规定的任务）的测试的关联（OR 2.30; CI 95% 1.00，5.28）。从我们的研究结果来看，居住在锰矿和加工厂附近的人由于吸入富含锰的粉尘而患有早期运动缺陷。(c)2006 Elsevier B.V保留所有权利。
Overexposure to manganese (Mn) causes neurotoxicity (a Parkinson-like syndrome) or psychiatric damage ("manganese madness"). Several studies have shown alterations to motor and neural behavior associated with exposure to Mn in the workplace. However, there are few studies on the effects of environmental exposure of whole populations. We studied the risk of motor alterations in people living in a mining district in Mexico. We studied 288 individual people (168 women and 120 men) from eight communities at various distances from manganese extraction or processing facilities in the district of Molango. We measured manganese concentrations in airborne particles, water, soil and crops and evaluated the possible routes of Mn exposure. We also took samples of people's blood and determined their concentrations of Mn and lead (Pb). We used "Esquema de Diagnostico Neuropsicologico" Ardila and Ostrosky-Solis's neuropsychological battery to evaluate motor functions. Concentrations of Mn in drinking water and maize grain were less than detection limits at most sampling sites. Manganese extractable by DTPA in soils ranged between 6 and 280 mg kg(-1) and means were largest close to Mn extraction or processing facilities. Air Mn concentration ranged between 0.003 and 5.86 mu g/m(3); the mean value was 0.42 mu g/m(3) and median was 0.10 mu g/m(3), the average value (geometric mean) resulted to be 0.13 mu g/m(3). Mean blood manganese concentration was 10.16 mu g/l, and geometric mean 9.44 mu g/l, ranged between 5.0 and 31.0 mu g/l. We found no association between concentrations of Mn in blood and motor tests. There was a statistically significant association between Mn concentrations in air and motor tests that assessed the coordination of two movements (OR 3.69; 95% Cl 0.9, 15.13) and position changes in hand movements (OR 3.09; CI 95% 1.07, 8.92). An association with tests evaluating conflictive reactions (task that explores verbal regulations of movements) was also found (OR 2.30; Cl 95% 1.00, 5.28). It seems from our results that people living close to the manganese mines and processing plants suffer from an incipient motor deficit, as a result of their inhaling manganese-rich dust. (c) 2006 Elsevier B.V All rights reserved.