Optofluidic phantom mimicking optical properties of porcine livers.
Optofluidic phantom mimicking optical properties of porcine livers.
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DOI：
10.1364/boe.2.001877
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发表时间：
2011-07-01
影响因子：
3.4
通讯作者：
McShane MJ
中科院分区：
文献类型：
--
作者：
Long R;King T;Akl T;Ericson MN;Wilson M;Coté GL;McShane MJ
评估肝移植疗效的一种策略是监测移植后的灌注和氧合。正在开发一种植入式光学传感器，以克服当前监测方法的不足。为了促进传感器设计，同时最大限度地减少动物使用，开发了一种基于聚二甲基硅氧烷 (PDMS) 的肝脏模型，以模拟猪肝脏在 630-1000 nm 波长范围内的光学特性和肝实质的解剖几何形状。使用软光刻在有色弹性体中构建微流体通道，可以实现具有 15mm 正弦通道的六边形肝小叶的二维近似，这将允许灌注模拟血液的液体，从而促进肝脏灌注和氧合监测系统的开发。
One strategy for assessing efficacy of a liver transplant is to monitor perfusion and oxygenation after transplantation. An implantable optical sensor is being developed to overcome inadequacies of current monitoring approaches. To facilitate sensor design while minimizing animal use, a polydimethylsiloxane (PDMS)-based liver phantom was developed to mimic the optical properties of porcine liver in the 630-1000 nm wavelength range and the anatomical geometry of liver parenchyma. Using soft lithography to construct microfluidic channels in pigmented elastomer enabled the 2D approximation of hexagonal liver lobules with 15mm sinusoidal channels, which will allow perfusion with blood-mimicking fluids to facilitate the development of the liver perfusion and oxygenation monitoring system.