Chromosomal chaos and cancer
Chromosomal chaos and cancer
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DOI：
10.1038/scientificamerican0507-52
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发表时间：
2007-05-01
影响因子：
3
通讯作者：
Duesberg, Peter
中科院分区：
文献类型：
--
作者：
Duesberg, Peter
在过去的30年里，人类关键基因的某些突变是所有癌症的根源，这一理论一直主导着研究。然而，尽管研究人员试图证明少数这样的致癌基因可以单独将正常细胞转化为恶性细胞，但没有一个成功。但在每一个已知的癌症病例中，单个基因很可能含有突变，但携带数千个基因的整个染色体也严重混乱-复制，断裂，结构重排或完全缺失。越来越多的证据表明，染色体水平上的这种混乱不仅仅是恶性肿瘤的副作用，就像流行的模型一样，而是癌症的直接原因和驱动力。
The theory that certain mutations in key human genes are at the root of all cancers has dominated research for the past 30 years. Yet despite all the attempts of investigators to demonstrate that a handful of such oncogenes alone can transform normal cells into malignant ones, none have succeeded. But in every known instance of cancer, individual genes may well contain mutations, but entire chromosomes, which carry thousands of genes, are also severely scrambled- duplicated, broken, structurally rearranged or missing entirely. Growing evidence suggests that this chaos on the chromosomal level is not just a side effect of malignancy,as the prevailing model holds, but the direct cause and driving force of cancer.