Genes that regulate both development and longevity in Caenorhabditis elegans.
Genes that regulate both development and longevity in Caenorhabditis elegans.
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发表时间：
1995-04
期刊：
影响因子：
3.3
通讯作者：
P. L. Larsen;P. Albert;D. Riddle
中科院分区：
文献类型：
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作者：
P. L. Larsen;P. Albert;D. Riddle
线虫秀丽隐杆线虫响应过度拥挤和有限的食物条件下，逮捕发展作为一个dauer幼虫。遗传分析的突变，改变dauer幼虫形成（daf突变）提出了沿着与dauer与非dauer发展更新的遗传途径。daf-2和daf-23基因的突变使成年寿命加倍，而位于该途径的单独分支中的其他四个子代组成基因（daf-1、daf-4、daf-7和daf-8）的突变则不会。增加的寿命被daf-16突变完全抑制，部分在daf-2; daf-18双突变体中。根据用于表征Daf表型的相同菌株和生长条件，提出了用于确定成虫寿命的遗传途径。daf-2、daf-12双突变体以等位基因特异的方式影响dauer幼虫的形成和成虫的寿命。daf-12的突变并不能延长成体的寿命，但是daf-2和daf-12突变等位基因的某些组合几乎使寿命增加了四倍。这种协同效应并不能等同地延长可育期，但却是在后生动物中观察到的最大的寿命遗传延长。
The nematode Caenorhabditis elegans responds to conditions of overcrowding and limited food by arresting development as a dauer larva. Genetic analysis of mutations that alter dauer larva formation (daf mutations) is presented along with an updated genetic pathway for dauer vs. nondauer development. Mutations in the daf-2 and daf-23 genes double adult life span, whereas mutations in four other dauer-constitutive genes positioned in a separate branch of this pathway (daf-1, daf-4, daf-7 and daf-8) do not. The increased life spans are suppressed completely by a daf-16 mutation and partially in a daf-2; daf-18 double mutant. A genetic pathway for determination of adult life span is presented based on the same strains and growth conditions used to characterize Daf phenotypes. Both dauer larva formation and adult life span are affected in daf-2; daf-12 double mutants in an allele-specific manner. Mutations in daf-12 do not extend adult life span, but certain combinations of daf-2 and daf-12 mutant alleles nearly quadruple it. This synergistic effect, which does not equivalently extend the fertile period, is the largest genetic extension of life span yet observed in a metazoan.