Imaging the aged brain: pertinence and methods.
Imaging the aged brain: pertinence and methods.
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DOI：
10.21037/qims.2019.05.06
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发表时间：
2019-05
影响因子：
2.8
通讯作者：
Hannah Humayun;Junjie Yao
中科院分区：
文献类型：
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作者：
Hannah Humayun;Junjie Yao
全球人口正在加速老龄化。随着年龄的增长，执行工作记忆任务和快速处理的能力变得越来越困难。随着国民平均寿命的增加和年龄相关疾病患病率的上升，讨论从老年大脑成像中可以获得的独特视角是恰当的。在结构，功能，血流和神经血管耦合的差异存在于健康的老年人的大脑和患病的大脑中，尚未被探索到他们的全面深入，在当代成像研究。从光学成像到磁共振成像（MRI）再到光声断层扫描等更新技术的成像方法，每种方法都在对老年大脑进行成像方面提供了独特的优势和挑战。本文将首先总结老年人大脑成像的重要性和挑战，然后提供潜在的成像模式及其代表性应用的分析。脑成像的潜在突破也被设想。
The global population is ageing at an accelerating speed. The ability to perform working memory tasks together with rapid processing becomes increasingly difficult with increases in age. With increasing national average life spans and a rise in the prevalence of age-related disease, it is pertinent to discuss the unique perspectives that can be gained from imaging the aged brain. Differences in structure, function, blood flow, and neurovascular coupling are present in both healthy aged brains and in diseased brains and have not yet been explored to their full depth in contemporary imaging studies. Imaging methods ranging from optical imaging to magnetic resonance imaging (MRI) to newer technologies such as photoacoustic tomography each offer unique advantages and challenges in imaging the aged brain. This paper will summarize first the importance and challenges of imaging the aged brain and then offer analysis of potential imaging modalities and their representative applications. The potential breakthroughs in brain imaging are also envisioned.