New Roles for the External Globus Pallidus in Basal Ganglia Circuits and Behavior
New Roles for the External Globus Pallidus in Basal Ganglia Circuits and Behavior
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DOI：
10.1523/jneurosci.3252-14.2014
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发表时间：
2014-11-12
影响因子：
5.3
通讯作者：
Schmidt, Robert
中科院分区：
文献类型：
--
作者：
Gittis, Aryn H.;Berke, Joshua D.;Schmidt, Robert
识别基底神经节内特定细胞群和回路的方法的发展正在迅速改变我们理解这一复杂回路功能的能力。这次小型研讨会重点介绍了描述苍白球外段 (GPe) 神经回路的组织和功能的最新进展。尽管长期以来被认为是运动抑制“间接通路”中的同质结构，但 GPe 由许多不同的细胞类型和解剖子域组成，它们对运动和非运动行为特征有不同的贡献。在这里，我们利用病毒追踪、转基因小鼠、电生理学和行为方法等技术整合了最近的研究，以创建一个修订后的框架来理解 GPe 与健康和疾病行为的关系。
The development of methodology to identify specific cell populations and circuits within the basal ganglia is rapidly transforming our ability to understand the function of this complex circuit. This mini-symposium highlights recent advances in delineating the organization and function of neural circuits in the external segment of the globus pallidus (GPe). Although long considered a homogeneous structure in the motor-suppressing "indirect-pathway," the GPe consists of a number of distinct cell types and anatomical subdomains that contribute differentially to both motor and nonmotor features of behavior. Here, we integrate recent studies using techniques, such as viral tracing, transgenic mice, electrophysiology, and behavioral approaches, to create a revised framework for understanding how the GPe relates to behavior in both health and disease.