Consensus demonstrates four indicators needed to standardize burn wound infection reporting across trials in a single-country study (ICon-B study)
Consensus demonstrates four indicators needed to standardize burn wound infection reporting across trials in a single-country study (ICon-B study)
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DOI：
10.1016/j.jhin.2020.07.022
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发表时间：
2020-10-01
影响因子：
6.9
通讯作者：
Young, A.
中科院分区：
文献类型：
--
作者：
Davies, A.;Teare, L.;Young, A.
引言：需要循证干预来治疗烧伤伤口感染（BWI）。证据合成受到用于报告试验间BWI的指标异质性的限制。一套商定的最低限度指标将有助于连贯一致地报告生物武器倡议。烧伤感染共识研究的目的是实现专家共识的核心指标集（CIS）为BWI.Methods：CIS是建立通过开发一个长长的列表中确定的BWI指标从系统的审查和专家的意见。在一项德尔菲调查中，英国专家参与者根据日常实践中的使用情况、诊断的重要性和观察BWI患者的频率对指标进行了评级。指标包括在CIS中，如果>= 75%的参与者同意这是重要的诊断和日常实践中使用，和>= 50%的参与者认为它是经常观察到的BWI患者。结果：一百九十五个指标被确定从系统评价和减少到29个调查项目，通过合并具有相同的含义的项目。75名联合王国专家参加了德尔菲调查。经过一轮调查和与专家小组的共识会议后，CIS中包括四个项目：发热、扩散性红斑、白色细胞计数变化和病原微生物的存在。讨论和结论：为了促进证据合成，采用单一国家系统的、专家知情的方法来开发CIS，以便在报告BWI作为结果的试验中一致地报告。今后的工作需要国际专家对独联体进行核查。(C)2020由Elsevier Ltd代表The Healthcare Infection Society发布。
Introduction: Evidence-based interventions are needed to treat burn wound infection (BWI). Evidence syntheses have been limited by heterogeneity of indicators used to report BWI across trials. Consistent reporting of BWI would be facilitated by an agreed minimum set of indicators. The Infection Consensus in Burns study aimed to achieve expert consensus about a core indicator set (CIS) for BWI.Methods: The CIS was established through development of a long list of BWI indicators identified from a systematic review and expert input. In a Delphi survey, UK expert participants rated the indicators according to use in everyday practice, importance for diagnosis and frequency of observation in patients with BWI. Indicators were included in the CIS if >= 75% of participants agreed it was important for diagnosis and used in everyday practice, and >= 50% of participants rated it as frequently observed in patients with BWI.Results: One hundred and ninety-five indicators were identified from the systematic review and reduced to 29 survey items through merging of items with the same meaning. Seventy-five UK experts participated in the Delphi survey. Following a single survey round and a consensus meeting with an expert panel, four items were included in the CIS: pyrexia, spreading erythema, change in white cell count, and presence of pathogenic microbes.Discussion and conclusions: To facilitate evidence synthesis, a single -country systematic, expert -informed approach was taken to develop a CIS to be reported consistently across trials reporting BWI as an outcome. Future work requires verification of the CIS with international experts. (C) 2020 Published by Elsevier Ltd on behalf of The Healthcare Infection Society.