Circadian changes in homovanillic acid and ascorbate levels in the rat striatum using microprocessor-controlled voltammetry
Circadian changes in homovanillic acid and ascorbate levels in the rat striatum using microprocessor-controlled voltammetry
复制标题
使用微处理器控制伏安法观察大鼠纹状体中高香草酸和抗坏血酸水平的昼夜变化
DOI：
10.1016/0304-3940(82)90174-4
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发表时间：
1982
影响因子：
2.5
通讯作者：
W. Albery
中科院分区：
文献类型：
--
作者：
Robert D. O'Neill;Marianne Fillenz;W. Albery
用碳糊电极和微处理机控制的线性扫描伏安法，每隔12分钟同时测定自由活动大鼠纹状体细胞外抗坏血酸和高香草酸浓度的昼夜变化。这两种化合物在24小时内表现出相似的时间过程，在04.00小时达到峰值，在16.00小时左右降至最低。高香草酸的变化可能反映了与运动活动水平昼夜变化相关的多巴胺释放的变化，而抗坏血酸变化的来源和功能尚不清楚。
Circadian variations in the extracellular concentration of ascorbate and homovanillic acid in the striatum of unrestrained rats were measured simultaneously at 12 min intervals over periods of up to 48 h using carbon paste electrodes and microprocessor-controlled linear sweep voltammetry. Both compounds show a similar time course over a 24 h period, reaching a peak at 04.00 h and falling to a minimum at around 16.00 h. The changes in homovanillic acid probably reflec changes in dopamine release associated with circadian variations in the level of motor activity, while the origin and function of the ascorbate changes are unknown.