Circulating tumor cells: from bench to bedside.
Circulating tumor cells: from bench to bedside.
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DOI：
10.1146/annurev-med-050311-163404
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发表时间：
2013
影响因子：
10.5
通讯作者：
Cote RJ
中科院分区：
文献类型：
--
作者：
Balic M;Williams A;Lin H;Datar R;Cote RJ
循环肿瘤细胞（CTCs）是血液转移的替代生物标志物。近年来，人们对它们的探测越来越感兴趣。关于检测ctc及其预后相关性的能力有充分的证据，但它们在治疗反应监测中的预测价值在临床上更有意义。许多早期和转移性癌症的临床试验现在都将ctc作为监测参数，并且许多试图表征其分子特征的转化研究正在进行中。在定义CTCs的临床重要性方面已经取得了很大的进展，现在看来，我们可能会期望CTCs作为一种实时监测治疗反应的诊断肿瘤学工具得到更广泛的应用。新技术可能进一步促进ctc的分子表征和新治疗靶点的开发，可能为癌症患者带来更强大的治疗策略。由于ctc的检测和评估正成为越来越重要的诊断和预后工具，本综述的目的是将通过原发肿瘤和ctc分析获得的知识传达给肿瘤学家和医学专家，以管理癌症患者。
Circulating tumor cells (CTCs) represent a surrogate biomarker of hematogenous metastases. In recent years, their detection has gained increasing interest. There is ample evidence regarding the ability to detect CTCs and their prognostic relevance, but their demonstrated predictive value in therapeutic response monitoring is clinically even more meaningful. Many clinical trials in the early and metastatic cancer setting now include CTCs as a monitoring parameter, and numerous translational studies attempting their molecular characterization are under way. There has been great progress in defining the clinical importance of CTCs, and it now seems likely that we may expect wider implementation of CTCs as a diagnostic oncology tool to monitor therapeutic response in real time. Novel technologies may further facilitate molecular characterization of CTCs and development of novel therapeutic targets, possibly leading to more powerful treatment strategies for cancer patients. As the detection and evaluation of CTCs are becoming an increasingly important diagnostic and prognostic tool, the goal of this review is to communicate the knowledge obtained through analysis of primary tumors and CTCs to oncologists and medical specialists in managing patients with cancer.
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影响因子：
45.3
作者：
Cristofanilli, M;Hayes, DF;Terstappen, LWMM
通讯作者：
Terstappen, LWMM
影响因子：
158.5
作者：
Cristofanilli, M;Budd, GT;Hayes, DF
通讯作者：
Hayes, DF
DOI：
10.1186/bcr1783
发表时间：
2007
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Fehm T;Becker S;Duerr-Stoerzer S;Sotlar K;Mueller V;Wallwiener D;Lane N;Solomayer E;Uhr J
通讯作者：
Uhr J
影响因子：
11.2
作者：
Charafe-Jauffret E;Ginestier C;Iovino F;Wicinski J;Cervera N;Finetti P;Hur MH;Diebel ME;Monville F;Dutcher J;Brown M;Viens P;Xerri L;Bertucci F;Stassi G;Dontu G;Birnbaum D;Wicha MS
通讯作者：
Wicha MS
影响因子：
4.8
作者：
Buess, Martin;Rajski, Michal;Rochlitz, Christoph
通讯作者：
Rochlitz, Christoph