Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex.
Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex.
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DOI：
10.1523/jneurosci.0154-12.2012
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发表时间：
2012-06-06
期刊：
影响因子：
--
通讯作者：
Mori K
中科院分区：
文献类型：
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作者：
Igarashi KM;Ieki N;An M;Yamaguchi Y;Nagayama S;Kobayakawa K;Kobayakawa R;Tanifuji M;Sakano H;Chen WR;Mori K
嗅觉信号由嗅球通过僧帽细胞（MC）和簇状细胞（TC）传递到嗅皮质（OC）。然而，这两种类型的投射神经元在功能和轴突连接方面是否以及如何不同仍然知之甚少。气味反应和轴突投射模式之间的MC和TC在小鼠中通过可视化轴突的电生理学鉴定的单个神经元进行比较。TC表现出较短的发病潜伏期比MC可靠的反应。较短的潜伏期响应的TC保持在一个广泛的气味浓度范围内，而MCs只响应于强信号。此外，单个TC仅在OC的前部区域密集地投射到焦点目标，而单个MC分散地投射到所有OC区域。令人惊讶的是，在前OC区域，两种细胞类型投射到分离的子区域。这些结果表明，MCs和TC传输时间上不同的气味信息，以不同的OC目标。
Odor signals are conveyed from the olfactory bulb to the olfactory cortex (OC) by mitral cells (MCs) and tufted cells (TCs). However, whether and how the two types of projection neuron differ in function and axonal connectivity is still poorly understood. Odor responses and axonal projection patterns were compared between MCs and TCs in mice by visualizing axons of electrophysiologically-identified single neurons. TCs demonstrated shorter onset latency for reliable responses than MCs. The shorter latency response of TCs was maintained in a wide range of odor concentrations, whereas MCs responded only to strong signals. Furthermore, individual TCs projected densely to focal targets only in anterior areas of the OC, whereas individual MCs dispersedly projected to all OC areas. Surprisingly, in anterior OC areas, the two cell types projected to segregated sub-areas. These results suggest that MCs and TCs transmit temporally distinct odor information to different OC targets.