Altered functional connectivity associated with cognitive impairment in neuromyelitis optica spectrum disorder.
Altered functional connectivity associated with cognitive impairment in neuromyelitis optica spectrum disorder.
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DOI：
10.1016/j.msard.2022.104113
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发表时间：
2022-08
影响因子：
4
通讯作者：
Yang Yang-Yang;Qian Rui;Xiaojuan Wu;Xiang Chen;Shuting Han;Yan Yang;Xiaoyuan Wang;Peng Wu;
中科院分区：
文献类型：
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作者：
Yang Yang-Yang;Qian Rui;Xiaojuan Wu;Xiang Chen;Shuting Han;Yan Yang;Xiaoyuan Wang;Peng Wu;
背景认知功能障碍是视神经脊髓炎谱系障碍（NMOSD）患者的常见症状之一。然而，其潜在机制尚不清楚。静息状态功能磁共振成像（rs-fMRI）提供了揭示不同认知状态患者大脑活动模式的机会。因此，本研究调查了NMOSD认知受损（CI）患者主要认知网络内部和之间的功能连接（FC）异常及其与认知表现的相关性。方法选取34例NMOSD患者和39例健康对照（HC）。进行神经心理评估和磁共振成像扫描。根据神经心理学评价将患者分为CI组（n= 16）和认知保留组（CP;n= 18）。通过群体独立分量分析，选取了代表6个主要认知网络的7个分量。评估CI、CP和HC组间网络间和网络内FC的差异。计算NMOSD的FC值与神经心理学数据的相关性。结果CI组脑后默认网络（pDMN）内网络连通性较HC组降低（P< 0.05， GRF校正），显著性网络（SN）与pDMN、SN与右侧额顶叶网络（rFPN）间网络连通性较CP组和HC组降低。在整个NMOSD组中，FC值的改变与认知表现显著相关。结论pDMN内部、SN与pDMN或rFPN之间的连接断开可能提示NMOSD认知功能障碍的神经基础。
BackgroundCognitive impairment is one of the common symptoms in patients with neuromyelitis optica spectrum disorder (NMOSD). However, the underlying mechanism remains unclear. Resting-state functional magnetic resonance imaging (rs-fMRI) offers the opportunity to reveal the patterns of brain activity in patients with different cognitive states. Accordingly, this study investigated functional connectivity (FC) abnormalities within and between the main cognitive networks in cognitively impaired (CI) patients with NMOSD and their correlations with cognitive performance.MethodsThirty-four patients with NMOSD and 39 healthy controls (HC) were included. Neuropsychological evaluations and rs-fMRI scanning were performed. Patients were classified as CI (n= 16) or cognitively preserved (CP;n= 18) according to neuropsychological evaluations. Seven components representing six main cognitive networks were selected by group independent component analysis. The differences in inter- and intranetwork FC among CI, CP, and HC groups were assessed. The correlation between FC values and neuropsychological data in NMOSD was calculated.ResultsThe CI group showed decreased intranetwork connectivity in the posterior default mode network (pDMN) compared with the HC group (P< 0.05, GRF corrected), and decreased internetwork connectivity between the salience network (SN) and pDMN, and between the SN and right frontoparietal network (rFPN) compared with CP and HC groups. The altered FC values were significantly correlated with cognitive performance in the whole NMOSD group.ConclusionThe disconnection within the pDMN and between the SN and pDMN or rFPN might suggest the neural substrates underlying cognitive impairment in NMOSD.