COMPARATIVE EXPRESSION OF T9, T10, AND IA ANTIGENS ON ACTIVATED HUMAN T-CELL SUBSETS
COMPARATIVE EXPRESSION OF T9, T10, AND IA ANTIGENS ON ACTIVATED HUMAN T-CELL SUBSETS
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DOI：
10.1016/0198-8859(81)90021-5
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发表时间：
1981-01-01
期刊：
影响因子：
2.7
通讯作者：
REINHERZ, EL
中科院分区：
文献类型：
--
作者：
HERCEND, T;RITZ, J;REINHERZ, EL
利用单克隆抗体和间接免疫荧光检查了活化 T 淋巴细胞上发现的 3 种表面分子 T9、T10 和 Ia 的表达。这些抗原以特定的时间顺序出现在 T 淋巴细胞上，该时间顺序取决于特定的触发刺激。当 T 细胞被分为 T4+ 诱导剂和 T8+ 细胞毒性/抑制性淋巴细胞的各个子集时，在可溶性抗原刺激后，所有 3 种分子的表达仅限于 T4+ 子集。两个亚群在有丝分裂原或同种异体抗原刺激后均表达这些表面决定簇。 T 细胞激活过程中可能存在与独特细胞表面抗原的出现相关的连续阶段；不同的触发刺激可能以不同的方式激活 T 细胞群。
The expression of 3 surface molecules T9, T10 and Ia, which are found on activated T lymphocytes, was examined utilizing monoclonal antibodies and indirect immunofluorescence. These antigens appeared on T lymphocytes in a defined temporal sequence which was dependent on the specific triggering stimulus. When T cells were fractionated into individual subsets of T4+ inducer and T8+ cytotoxic/suppressor lymphocytes, the expression of all 3 molecules was restricted to the T4+ subset following soluble antigen stimulation. Both subsets expressed these surface determinants following mitogen or alloantigen stimulation. There may be successive stages in the T cell activation process associated with the appearance of unique cell surface antigen; various triggering stimuli probably activate T cell populations differently.