Cardiovascular risk factors in 2011 and secular trends since 2007: The Cardiovascular Risk in Young Finns Study
Cardiovascular risk factors in 2011 and secular trends since 2007: The Cardiovascular Risk in Young Finns Study
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DOI：
10.1177/1403494814541597
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发表时间：
2014-11-01
影响因子：
3.4
通讯作者：
Juonala, Markus
中科院分区：
文献类型：
--
作者：
Nuotio, Joel;Oikonen, Mervi;Juonala, Markus
目的：2011年的心血管风险因素水平以及2007年至2011年的4年变化使用芬兰年轻人心血管风险研究的随访数据进行了检查。研究人群包括2063名芬兰成年人，年龄在34 - 49岁之间（45%为男性）。血脂和血压水平，血糖和人体测量和生活方式的危险因素进行调查问卷。结果如下：2011年的平均总胆固醇水平为5.19 mmol/l，低密度脂蛋白（LDL）-胆固醇为3.27 mmol/l，高密度脂蛋白（HDL）-胆固醇为1.33 mmol/l，甘油三酯为1.34 mmol/l。使用美国糖尿病协会标准，在4.1%的参与者中观察到2型糖尿病（T2D），33.8%的参与者被诊断为前驱糖尿病（空腹血糖5.6 - 6.9 mmol/l或糖化血红蛋白5.7 - 6.4%）。2007年至2011年的显著变化（P <0.05）包括女性腰围增加（3.3%）。在两种性别中，收缩压（女性-3.0%，男性-4.0%）和舒张压（女性-3.0%，男性-3.3%）以及甘油三酯（女性-3.4%，男性-6.5%）在随访期间均降低。结论：以前观察到的LDL胆固醇水平的有利趋势在芬兰的年轻人和中年人样本中趋于平稳。甘油三酯和血压水平下降。超过三分之一的研究人群患有前驱糖尿病，可能会增加T2D的风险。
Aims: Cardiovascular risk factor levels in 2011 and 4-year changes between 2007 and 2011 were examined using data collected in follow-ups of the Cardiovascular Risk in Young Finns Study. Methods: The study population comprised 2063 Finnish adults aged 34-49 years (45% male). Lipid and blood pressure levels, glucose and anthropometry were measured and life style risk factors examined with questionnaires. Results: Mean total cholesterol level in 2011 was 5.19 mmol/l, low density lipoprotein (LDL)-cholesterol 3.27 mmol/l, high density lipoprotein (HDL)-cholesterol 1.33 mmol/l, and triglycerides 1.34 mmol/l. Using American Diabetes Association criteria, Type 2 diabetes (T2D) was observed in 4.1% and prediabetes (fasting glucose 5.6-6.9 mmol/l or glycated hemoglobin 5.7-6.4%) diagnosed for 33.8% of the participants. Significant changes (P < 0.05) between 2007 and 2011 included an increase in waist circumference (3.3%) in women. In both sexes, systolic (-3.0% in women, -4.0% in men) and diastolic (-3.0% in women, -3.3% in men) blood pressure and triglycerides (-3.4% in women, -6.5% in men) decreased during follow-up. Conclusions: Previously observed favorable trends in LDL-cholesterol levels have leveled off among a sample of young and middle-aged adults in Finland. Triglyceride and blood pressure levels have decreased. Over one-third of the study population had prediabetes and may be at increased risk for T2D.