Amino acid sequence of a major apoprotein from hen plasma very low density lipoproteins.
Amino acid sequence of a major apoprotein from hen plasma very low density lipoproteins.
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来自母鸡血浆极低密度脂蛋白的主要脱辅基蛋白的氨基酸序列。
DOI：
10.1016/s0021-9258(19)70102-1
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
A. Means
中科院分区：
文献类型：
--
作者：
R. Jackson;H. Y. Lin;L. Chan;A. Means
测定了白来窝鸡血浆极低密度脂蛋白中一个主要载脂蛋白的完整氨基酸序列。载脂蛋白，被命名为apoVLDL-II，包含两个相同的多肽链，每个多肽链由82个氨基酸残基组成，每个残基在第76个残基上由一个二硫键连接。在非蛋鸡或公鸡中，雌激素的施用会显著增加血浆甘油三酯水平（1,2）。Luskey等人(3)表明，雌激素的一个作用是增加极低密度脂蛋白（VLDIJ）蛋白的合成速率。这种诱导的机制可能是通过蛋黄蛋白mRNA的增加（4-6）。在最近的一篇报道中（71），从母鸡VLDL中分离了一个小分子量载脂蛋白，并在体外研究了它的合成
The complete amino acid sequence of a major apoprotein from white Leghorn hen plasma very low density lipoproteins has been determined. The apoprotein, designated apoVLDL-II, contains two identical polypeptide chains of 82 amino acid residues each which are linked by a single disulfide bond at residue 76. In nonlaying hens or in cockerels, the administration of estrogen dramatically increases the level of plasma triglycer- ides (1, 2). Luskey et al. (3) have shown that one effect of estrogen was to increase the rate of synthesis of the very low density lipoproteins (VLDIJ’ proteins. The mechanism for this induction is presumably through an increase in mRNA for the yolk proteins (4-6). In a recent report (71, a small molecular weight apoprotein from hen VLDL was isolated and its synthe- sis studied in an