Prognostic Value of Urinary Calprotectin, NGAL and KIM-1 in Chronic Kidney Disease
Prognostic Value of Urinary Calprotectin, NGAL and KIM-1 in Chronic Kidney Disease
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DOI：
10.1159/000492407
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发表时间：
2018-01-01
影响因子：
2.8
通讯作者：
Westhoff, Timm H.
中科院分区：
文献类型：
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作者：
Seibert, Felix S.;Sitz, Maximilian;Westhoff, Timm H.
背景/目的：尿生物标志物，如中性粒细胞明胶酶相关脂钙蛋白（NGAL）和肾损伤分子-1 (KIM-1)，不仅允许早期诊断急性肾损伤，而且在这种情况下提供预后信息。本前瞻性研究探讨尿液生物标志物NGAL、KIM-1和钙保护蛋白在慢性肾脏疾病（CKD）中是否也具有预后信息。方法：在143例包括糖尿病和高血压肾病、肾小球肾炎/血管炎和常染色体显性多囊肾病的稳定CKD患者中评估尿钙保护蛋白、NGAL和KIM-1浓度。为了排除急性或慢性肾损伤病例，将过去12个月eGFR波动bbb50 ml/min/1.73m(2)定义为排除标准。肾功能监测的中位随访时间为37个月。结果：在整个研究人群中，在调整了年龄、性别和基线eGFR的线性回归分析中，所有三种生物标志物都无法预测从基线到随访期间的δ eGFR和δ ACR。相反，基线ACR与δ eGFR显著相关(p
Background/Aims: Urinary biomarkers like neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) do not only allow an early diagnosis of acute kidney injury, but also provide prognostic information in this setting. The present prospective study investigates, whether the urinary biomarkers NGAL, KIM-1 and calprotectin have prognostic information in chronic kidney disease (CKD) as well. Methods: Urinary calprotectin, NGAL and KIM-1 concentrations were assessed in a study population of 143 patients with stable CKD comprising diabetic and hypertensive nephropathy, glomerulonephritis/vasculitis, and autosomal dominant polycystic kidney disease. An eGFR fluctuation > 5ml/min/1.73m(2) in the past 12 months was defined as an exclusion criterion in order to exclude cases with acute on chronic kidney injury. Renal function was monitored for a median follow-up of 37 months. Results: In the overall study population, all the three biomarkers failed to predict Delta eGFR and Delta ACR from baseline to follow-up in linear regression analysis adjusted for age, gender, and baseline eGFR. Contrarily, baseline ACR was significantly associated with Delta eGFR (p