Folate Administration Increases n-3 Polyunsaturated Fatty Acids in Rat Plasma and Tissue Lipids
Folate Administration Increases n-3 Polyunsaturated Fatty Acids in Rat Plasma and Tissue Lipids
复制标题
叶酸给药可增加大鼠血浆和组织脂质中的 n-3 多不饱和脂肪酸
DOI：
10.1055/s-0037-1614038
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发表时间：
2000
影响因子：
6.7
通讯作者：
María
中科院分区：
文献类型：
--
作者：
M. Pita;María
摘要 研究表明，叶酸缺乏会改变多不饱和脂肪酸 (PUFA) 代谢，从而导致心血管疾病的发生。我们研究了叶酸给药对血浆、血小板、红细胞、肠道和肝脏脂质的脂肪酸组成的影响。两组大鼠每天注射盐水溶液（对照组）或5-甲基四氢叶酸（MTHF）溶液（MTHF 组），持续 15 天。叶酸处理对 n-6 PUFA 引起的变化不是非常显着。 MTHF 大鼠的肝脏和肠道磷脂中的亚油酸仅降低，而花生四烯酸则不受叶酸给药的影响。然而，n-3 PUFA 显着增加血浆脂质成分以及血小板、红细胞和肠磷脂。众所周知，n-3 PUFA 具有抗血栓特性。因此，MTHF 给药后观察到的 n-3 PUFA 增加可能有助于预防血管疾病。
Summary It has been shown that folic acid deficiency can modify polyunsaturated fatty acid (PUFA) metabolism and thus could contribute to the development of cardiovascular diseases. We have studied the effect of folate administration on fatty acid composition of plasma, platelet, erythrocyte, intestinal and liver lipids. Two groups of rats were daily injected with either saline solution (control group) or 5-methyl-tetrahydrofolate (MTHF) solution (MTHF group) for 15 days. Changes induced by folate treatment on n-6 PUFA were not very significant. Linoleic acid only decreased in liver and intestinal phospholipids of MTHF rats whereas arachidonic acid was unaffected by folate administration. However, n-3 PUFA significantly increased in plasma lipid fractions and in platelet, erythrocyte and intestinal phospholipids. It is well known that n-3 PUFA show antithrombotic properties. Thus, the increase of n-3 PUFA observed after MTHF administration might contribute to the prevention of vascular disorders.