Catalytic asymmetric hydroxymethylation of silicon enolates using an aqueous solution of formaldehyde with a chiral scandium complex
Catalytic asymmetric hydroxymethylation of silicon enolates using an aqueous solution of formaldehyde with a chiral scandium complex
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DOI：
10.1021/ja047896i
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发表时间：
2004-10-06
影响因子：
15
通讯作者：
Kobayashi, S
中科院分区：
文献类型：
--
作者：
Ishikawa, S;Hamada, T;Kobayashi, S
实现了硅烯醇化物的催化不对称羟甲基化。在该反应中，甲醛的水溶液可以实现一个简单和安全的程序，并已获得高的对映选择性。这是在水介质中手性钪配合物催化不对称反应的第一个例子。
Catalytic asymmetric hydroxymethylation of silicon enolates has been achieved. In this reaction, an aqueous solution of formaldehyde can be used to realize an easy and safe procedure, and high enantioselectivities have been obtained. This is the first example of catalytic asymmetric reactions in aqueous media with a chiral scandium complex.