Uncoordinated firing rate changes of striatal fast-spiking interneurons during behavioral task performance.
Uncoordinated firing rate changes of striatal fast-spiking interneurons during behavioral task performance.
复制标题
DOI：
10.1523/jneurosci.2192-08.2008
复制
发表时间：
2008-10-01
期刊：
影响因子：
--
通讯作者：
Berke JD
中科院分区：
文献类型：
--
作者：
Berke JD
基底神经节回路对决策做出关键贡献。已证明快速尖峰GABA能中间神经元（FSI）对纹状体中型多棘神经元的分布式、同步前馈抑制对于抑制不想要的动作是重要的，并且已在患有抽动秽语综合征的人类患者中发现FSI的缺陷。然而，还没有研究探讨纹状体FSI如何改变他们的活动在行为任务。在这里，我描述了36个假定的纹状体FSI记录在大鼠在良好的实践表现的径向迷宫赢得停留任务。虽然大多数FSI表现出强大的任务相关的活动，发射率变化的时间模式是非常特殊的。与其他类型的纹状体神经元相比，FSI对主要任务事件（如指令线索或奖励）的协调群体反应很少或根本没有。即使当多个FSI同时记录从同一个局部区域的纹状体，放电率的变化是不同的，并没有明确的证据同步发射发现使用交叉相关图（18 FSI对检查）。这些结果表明，FSI发挥更复杂的作用，在纹状体微电路实现的信息处理比目前的理论模型。
Basal ganglia circuits make key contributions to decision-making. Distributed, synchronous feed-forward inhibition of striatal medium spiny neurons by fast-spiking GABAergic interneurons (FSIs) has been argued to be important for the suppression of unwanted actions, and a deficit in FSIs has been found in human patients with Tourette Syndrome. However, no studies have yet examined how striatal FSIs change their activity during behavioral tasks. Here I describe 36 presumed striatal FSIs recorded in rats during well-practiced performance of a radial maze win-stay task. Although most FSIs showed robust task-related activity, the temporal patterns of firing rate change were highly idiosyncratic. In contrast to other classes of striatal neurons, FSIs showed little or no coordinated population response to major task events such as instruction cues or rewards. Even when multiple FSIs were recorded simultaneously from the same local region of striatum, firing rate changes were dissimilar, and no clear evidence for synchronous firing was found using cross-correlograms (18 FSI pairs examined). These results suggest that FSIs play a more complex role in the information processing achieved by striatal microcircuits than supposed by current theoretical models.