Verbal working memory impairment in schizophrenia patients and their first-degree relatives: Evidence from the digit span task
Verbal working memory impairment in schizophrenia patients and their first-degree relatives: Evidence from the digit span task
复制标题
DOI：
10.1176/appi.ajp.157.2.275
复制
发表时间：
2000-02-01
影响因子：
17.7
通讯作者：
Iacono, WG
中科院分区：
文献类型：
--
作者：
Conklin, HM;Curtis, CE;Iacono, WG
目的：关于精神分裂症患者言语工作记忆缺陷的证据一直不一致。很少有研究评估精神分裂症患者的一级亲属的言语工作记忆，他们可能具有精神分裂症的遗传素质，但没有与慢性精神疾病相关的潜在混淆。方法：采用韦氏数字广度测验对52例精神分裂症患者、56例一级亲属和73例非精神科对照进行言语工作记忆测试。结果：非精神病患者亲属在前向数字广度任务上无损害，但在后向数字广度任务上有损害，后向数字广度任务是言语工作记忆的测量。精神分裂症患者在前向和后向数字广度任务上均表现出损害。结论：前向和后向数字广度任务具有不同的认知能力，与精神分裂症的素质有不同的关联。与精神分裂症相关的工作记忆缺陷似乎是泛化的，并不局限于空间通道。
Objective: The evidence for verbal working memory deficits in schizophrenia has been inconsistent. Few studies have evaluated verbal working memory in the first-degree relatives of schizophrenia patients, who likely share the genetic diathesis for schizophrenia but not the potential confounds associated with chronic mental illness. Method: The Wechsler Digit Span Task was used to investigate verbal working memory in 52 schizophrenia patients, 56 of their first-degree relatives, and 73 nonpsychiatric comparison subjects. Results: The nonpsychotic relatives showed no impairment on the forward digit span task, a measure of general attention, but did show impairment on the backward digit span task, a measure of verbal working memory. Schizophrenia patients showed impairment on both the forward and backward digit span tasks. Conclusions: These results indicate that the forward and backward digit span tasks tap different cognitive abilities that are differentially associated with the diathesis for schizophrenia. Working memory deficits associated with schizophrenia appear to be generalized and not limited to the spatial modality.