MAST CELLS IN NORMAL AND SECTIONED PERIPHERAL NERVE
MAST CELLS IN NORMAL AND SECTIONED PERIPHERAL NERVE
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DOI：
10.1007/bf00368249
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发表时间：
1965-01-01
期刊：
影响因子：
--
通讯作者：
SOURANDER, P
中科院分区：
文献类型：
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作者：
ENERBACK, L;OLSSON, Y;SOURANDER, P
本文对正常和切片周围神经中肥大细胞的性质和数量分布进行了研究。在正常大鼠的神经外膜结缔组织中发现了相当数量的肥大细胞，在神经内膜中也发现了散在的肥大细胞。神经切片后，在整个坐骨神经的远端部分的神经内膜肥大细胞的数量增加了约5倍，正常和切片的神经中的肥大细胞颗粒显示出与其他组织中的肥大细胞颗粒相同的组织化学性质，即强烈的甲苯胺蓝异染性，耐酒精脱水，在pH低于1时染料结合和异染性持续存在。此外，异染性不受染色前用氯仿和甲醇提取的影响。肥大细胞颗粒的异染成分可以通过这些特性与正常和切片神经中的其他异染结构区分开来。讨论了这些发现的意义，特别是神经内膜肥大细胞与髓鞘降解的可能关系。
An investigation is reported on the properties and quantitative distribution of mast cells in normal and sectioned peripheral nerve. A considerable number of mast cells has been found in the epineurial connective tissue in normal rats, as well as scattered mast cells in the endoneurium. After nerve section there was an about five-fold increase in the number of endoneurial mast cells throughout the distal part of the sciatic nerve.The mast cell granules in normal and sectioned nerve showed the same histochemical properties as mast cell granules in other tissues, i.e. strong toluidine blue metachromasia resistant to alcohol dehydration, and persistence of dye binding and metachromasia at pH below 1. Furthermore, the metachromasia is unaffected by extraction with chloroform and methanol prior to staining. The metachromatic component of the mast cell granules can be differentiated by these properties from other metachromatic structures in normal and sectioned nerve. The significance of the findings is discussed, in particular the possible relation of endoneurial mast cells to the degradation of myelin.