A Neural Representation of Naturalistic Motion-Guided Behavior in the Zebrafish Brain.
A Neural Representation of Naturalistic Motion-Guided Behavior in the Zebrafish Brain.
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斑马鱼大脑中自然运动引导行为的神经表征。
DOI：
10.1016/j.cub.2020.04.043
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Portugues,Ruben
中科院分区：
文献类型：
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作者：
Yildizoglu,Tugce;Riegler,Clemens;Fitzgerald,JamesE;Portugues,Ruben
所有动物都必须将模糊的感觉数据转化为成功的行为。这就要求感官表征准确地反映自然刺激和行为的统计数据。多项研究表明，在自然条件下，视觉运动处理的准确性得到了调整，但提取这些线索和实现运动引导行为的感觉运动回路仍然不清楚。在这里，我们表明，幼体斑马鱼视网膜提取的自然运动线索的多样性，和retinorecipient pretectum组织这些线索周围的行为元素。我们发现，高阶运动刺激，滑翔机，诱导optomotor行为匹配的期望从自然场景分析。然后，我们图像视网膜神经节细胞终端和顶盖前神经元的活动。视网膜表现出方向选择性的反应，在滑翔机的刺激，和解剖集群的前顶盖神经元响应与幅度匹配的行为。因此，外围计算反映了自然输入的统计数据，而中枢大脑活动则精确地编码了行为所需的信息。这一普遍原则可以组织跨动物物种的感觉运动转换。
All animals must transform ambiguous sensory data into successful behavior. This requires sensory representations that accurately reflect the statistics of natural stimuli and behavior. Multiple studies show that visual motion processing is tuned for accuracy under naturalistic conditions, but the sensorimotor circuits extracting these cues and implementing motion-guided behavior remain unclear. Here we show that the larval zebrafish retina extracts a diversity of naturalistic motion cues, and the retinorecipient pretectum organizes these cues around the elements of behavior. We find that higher-order motion stimuli, gliders, induce optomotor behavior matching expectations from natural scene analyses. We then image activity of retinal ganglion cell terminals and pretectal neurons. The retina exhibits direction-selective responses across glider stimuli, and anatomically clustered pretectal neurons respond with magnitudes matching behavior. Peripheral computations thus reflect natural input statistics, whereas central brain activity precisely codes information needed for behavior. This general principle could organize sensorimotor transformations across animal species.