Health-related Quality of Life of Bone Marrow versus Peripheral Blood Stem Cell Donors: A Prespecified Subgroup Analysis from a Phase III RCT-BMTCTN Protocol 0201
Health-related Quality of Life of Bone Marrow versus Peripheral Blood Stem Cell Donors: A Prespecified Subgroup Analysis from a Phase III RCT-BMTCTN Protocol 0201
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DOI：
10.1016/j.bbmt.2013.10.024
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发表时间：
2014-01-01
影响因子：
4.3
通讯作者：
Wingard, John R.
中科院分区：
文献类型：
--
作者：
Switzer, Galen E.;Bruce, Jessica G.;Wingard, John R.
造血干细胞可以通过骨髓(BM)抽吸法或外周血干细胞(PBSC)采集法从无血缘关系的捐献者那里获得。在与捐赠者无关的背景下，前瞻性随机试验没有证据表明捐赠者的相对健康相关生活质量(HRQOL)收益/成本。这项前瞻性纵向调查的目标是描述和比较332名骨髓捐献者和外周血干细胞捐献者与捐献相关的HRQOL体验。捐献者在捐献前、捐献后48小时、每周一次直到完全康复，以及捐献后6个月和12个月接受采访。在捐赠前，骨髓捐赠者的困惑程度较低，担忧较少，对捐赠的准备更充分。捐献后不久，骨髓捐赠者报告了更多的身体副作用。BM捐赠者还报告说，他们的社会活动受到了更多与捐赠有关的影响。然而，骨髓移植捐赠者的心理状况有所改善，而且更有可能表示捐赠使他们的生活更有意义。两组捐赠者的经历几乎不再有长期差异，包括从捐献后3周开始没有恢复时间差异。尽管骨髓移植捐赠者在短期内可能会经历更多的身体压力和更多的心理益处，但从长期来看，骨髓移植捐赠者和PBSC捐赠者的HRQL结果是相似的。爱思唯尔公司代表美国血液和骨髓移植学会出版。
Hematopoietic stem cells can be procured from unrelated donors via either the bone marrow (BM) aspiration or peripheral blood stem cell (PBSC) collection methods. There is no evidence from prospective randomized trials in the unrelated donor setting about the relative health-related quality-of-life (HRQoL) benefits/costs to donors. The goals of this prospective longitudinal investigation were to describe and compare the donation-related HRQoL experiences of 332 BM and PBSC donors. Donors were interviewed before donation, 48 hours after donation, weekly until fully recovered, and at 6 and 12 months after donation. Before donation, BM donors had lower confusion, fewer concerns, and were more prepared for donation. Shortly after donation, BM donors reported more physical side effects. BM donors also reported more donation-related impact on their social activities. However, BM donors reported somewhat better psychological status and were more likely to indicate that the donation made their lives more meaningful. There were virtually no longer term differences in the experiences of the 2 donor groups, including no recovery time difference beginning 3 weeks after donation. Although BM donors may experience the process as more physically stressful and more psychologically beneficial in the short term, the longer term HRQoL consequences of BM and PBSC donors are similar. Published by Elsevier Inc. on behalf of American Society for Blood and Marrow Transplantation.