CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation.
CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation.
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DOI：
10.4049/jimmunol.1202183
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发表时间：
2013-03-15
期刊：
影响因子：
--
通讯作者：
Jenkins MK
中科院分区：
文献类型：
--
作者：
Nelson RW;McLachlan JB;Kurtz JR;Jenkins MK
CD4+ memory-phenotype T cells decline over time when generated in response to acute infections cleared by other components of the immune system. It was therefore of interest to assess the stability of CD4+ T cells during a persistent Salmonella infection, which is typical of persistent phagocytic infections that are controlled by this lymphocyte subset. We found that CD4+ T cells specific for Salmonella peptide:MHCII ligands were numerically stable for greater than a year after initial oral infection. This stability was associated with peptide:MHCII-driven proliferation by a small number of T cells in the secondary lymphoid organs that harbored bacteria. The persistent population consisted of multi-functional Th1 cells that induced PD-1 and became exhausted when transferred to hosts expressing the specific peptide:MHCII ligand in all parts of the body. Thus, persistent infection of phagocytes produced a CD4+ T cell population that was stably maintained by low-level peptide:MHCII presentation.
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影响因子：
32.4
作者：
Marshall HD;Chandele A;Jung YW;Meng H;Poholek AC;Parish IA;Rutishauser R;Cui W;Kleinstein SH;Craft J;Kaech SM
通讯作者：
Kaech SM
DOI：
10.1126/science.1201730
发表时间：
2011-03-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Pape KA;Taylor JJ;Maul RW;Gearhart PJ;Jenkins MK
通讯作者：
Jenkins MK
影响因子：
32.4
作者：
Moon, James J.;Chu, H. Hamlet;Jenkins, Marc K.
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Jenkins, Marc K.
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影响因子：
15.3
作者：
Monack, DM;Bouley, DM;Falkow, S
通讯作者：
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DOI：
10.1084/jem.194.10.1497
发表时间：
2001-11-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Belkaid Y;Hoffmann KF;Mendez S;Kamhawi S;Udey MC;Wynn TA;Sacks DL
通讯作者：
Sacks DL