A novel model using mean platelet volume and neutrophil to lymphocyte ratio as a marker of nonalcoholic steatohepatitis in NAFLD patients: multicentric study
A novel model using mean platelet volume and neutrophil to lymphocyte ratio as a marker of nonalcoholic steatohepatitis in NAFLD patients: multicentric study
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DOI：
10.1097/meg.0000000000000486
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发表时间：
2016-01-01
影响因子：
2.1
通讯作者：
Awad, Mahmoud
中科院分区：
文献类型：
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作者：
Abdel-Razik, Ahmed;Mousa, Nasser;Awad, Mahmoud
背景和目的非酒精性脂肪性肝病（NAFLD）是进行性和慢性肝损伤的主要原因。在许多疾病中，平均血小板体积（MPV）和嗜中性粒细胞-淋巴细胞比率（N/L比率）可能被认为是廉价和简单的炎症标志物。我们的目的是调查MPV和N/L比值的临床效用，以预测纤维化在NAFLD患者和非酒精性脂肪性肝炎（NASH）的存在。材料和方法共873例活检证实的NAFLD患者和150名健康对照。患者分为两组：非NASH组（n=753）和NASH组（n=120）。记录肝活检、MPV、淋巴细胞和中性粒细胞计数;计算N/L比值。结果NASH患者的MPV较非NASH患者高（分别为10.9 ± 1.8和9.5 ± 1.6fl，P
Background and aimNonalcoholic fatty liver disease (NAFLD) is a leading cause of progressive and chronic liver injury. Mean platelet volume (MPV) and the neutrophil-lymphocyte ratio (N/L ratio) may be considered cheap and simple markers of inflammation in many disorders. We aimed to investigate the clinical utility of MPV and the N/L ratio to predict fibrosis in NAFLD patients and the presence of nonalcoholic steatohepatitis (NASH).Materials and methodsA total of 873 patients with biopsy-proven NAFLD and 150 healthy controls were included. Patients were divided into two groups: non-NASH group (n=753) and NASH group (n=120). Liver biopsy, MPV, lymphocyte, and neutrophil counts were registered; the N/L ratio was calculated. Proinflammatory cytokines (tumor necrosis factor- and interleukin-6) were measured by an ELISA.ResultsNASH patients had higher MPV compared with non-NASH patients (10.91.8 and 9.5 +/- 1.6fl, respectively, P