Adherence and accumulation of oral streptococci
Adherence and accumulation of oral streptococci
复制标题
DOI：
10.1016/0966-842x(94)90114-k
复制
发表时间：
1994-01-01
影响因子：
15.9
通讯作者：
Jenkinson, Howard F.
中科院分区：
文献类型：
--
作者：
Jenkinson, Howard F.
细胞粘附是人类口腔微生物定植的核心，人类口腔是超过300种不同细菌的家园，包括10 -20种不同的链球菌。粘附于口腔组织使细菌能够抵抗清除，因此是感染和入侵的前奏。链球菌具有广泛的粘附机制，使它们能够结合沉积在口腔各种表面上的唾液成分。它们还粘附于其他口腔细菌，这一过程称为共聚集，通常涉及蛋白质-碳水化合物（凝集素样）相互作用。微生物群之间的共聚集（或共粘附）尚未在任何其他具有高度生态复杂性的系统中得到证明，这表明这些相互作用在口腔微生物群落的发展中具有重要意义。然而，在定义口腔链球菌的重要粘附分子方面的进展相对缓慢，主要是因为存在与唾液膜和细胞表面结合的各种模式，这使得粘附过程的解剖成为一个具有挑战性的问题。最近发表了几篇关于口腔细菌粘附的综述：一篇强调了粘附于菌膜和宿主组织的分子复杂性，另一篇强调了共聚集相互作用的特异性及其与细菌进入菌斑的时间增长的关系。本文考虑了一些机制，参与口腔链球菌的粘附和积累。不同的链球菌物种优先定殖于不同的口腔部位，并共同粘附于不同范围的细菌，因此各种口腔链球菌中的每一种都有可能在不同的口腔部位中生长。
C ell adherence is central to microbial colonization of the human oral cavity, home to over 300 different species of bacteria, including lo-20 different species of streptococci. Adherence to oral tissues allows bacteria to resist clearance, and so is the prelude to infection and invasion. The streptococci have a vast repertoire of adherence mechanisms enabling them to bind to salivary components that are deposited on the various surfaces in the mouth. They also adhere to other oral bacteria, a process referred to as coaggregation and which usually involves protein-carbohydrate(lectin-like) interactions. Coaggregation(or coadherence) between the microbiota has not been demonstrated to such an extent in any other system with a high degree of ecological complexity, suggesting that these interactions are significant in the development of oral microbial communities. However, progress in defining the important adhesive molecules of oral streptococci has been relatively slow, mainly because there are various modes of binding to salivary pellicles and cell surfaces, which has made dissection of the processes involved in adhesion a challenging problem. Several reviews of oral bacterial adherence have been published recently: one emphasized the molecular complexity of adherence to pellicle and host tissuesI, another the specificity of coaggregation interactions and their relationship to the temporal accretion of bacteria into plaques2. This article considers some of the mechanisms that are involved in the adherence and accumulation of oral streptococci. Different streptococcal species preferentially colonize different oral sites and coadhere to a different range of bacteria, and so it is possible that each of the various oral