Angelica sinensis polysaccharide extends lifespan and ameliorates aging-related diseases via insulin and TOR signaling pathways, and antioxidant ability in Drosophila
Angelica sinensis polysaccharide extends lifespan and ameliorates aging-related diseases via insulin and TOR signaling pathways, and antioxidant ability in Drosophila
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DOI：
10.1016/j.ijbiomac.2023.124639
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发表时间：
2023-05-09
影响因子：
8.2
通讯作者：
He，Jianzheng
中科院分区：
文献类型：
--
作者：
Tuo，Wenjuan;Wang，Shuwei;He，Jianzheng
当归多糖（Angelica sinensis polysaccharides， ASP）是当归（Angelica sinensis， AS）的主要活性成分之一，在天然药物中应用广泛，具有抗氧化、抗炎、增强免疫等多种药理活性。但其抗衰老的药理作用还有待进一步研究。本研究利用黑腹果蝇模型，检测ASP对健康衰老和衰老相关疾病的有益作用及其机制。结果表明，口服ASP主要通过抑制胰岛素信号通路（IIS）和TOR信号通路，增强抗氧化能力，显著延长老龄果蝇寿命，增加繁殖，提高攀爬能力，增强饥饿和氧化应激抵抗能力。此外，补充ASP可以通过抑制肠道干细胞（ISCs）过度增殖和氧化损伤来防止衰老诱导的肠道稳态失衡，通过挽救衰老果蝇的睡眠节律来改善睡眠障碍，并对a β42转基因果蝇具有神经保护作用。综上所述，我们的发现揭示了ASP可以延长寿命，改善健康老龄化，并最终减少与年龄相关疾病的发病率的可能性。它有望成为抗衰老干预和治疗衰老相关疾病的候选药物。
Angelica sinensispolysaccharide (ASP) is one of the principal active components ofAngelica sinensis(AS) that is widely used in natural medicine and has various pharmacological activities, including antioxidant, anti-inflammatory, and enhancing immunity. However, its pharmacological role of anti-aging needs to be clarified. Here, we detected the beneficial effect and mechanism of ASP on healthy aging and aging-related diseases using theDrosophila melanogastermodel. The results showed that oral administration of ASP remarkably extended lifespan, increased reproduction, improved climbing ability, and increased resistance to starvation and oxidative stress in aged flies, mainly via inhibiting insulin signaling (IIS) and TOR signaling and boosting antioxidant ability. Further, ASP supplementation protected against aging-induced intestinal homeostasis imbalance via inhibiting intestinal stem cells (ISCs) hyperproliferation and oxidative damage, improved sleep disorders via rescuing sleep rhythm in aged flies, and had a neuroprotective effect on Aβ42 transgenic flies. Taken together, our findings shed light on the possibility that ASP could increase lifespan, improve healthy aging, and ultimately reduce the incidence of age-related illnesses. It holds promise as a candidate for anti-aging intervention and treatment for aging-associated disorders.