MARKERS OF IMMUNE STIMULATION IN THE CEREBROSPINAL-FLUID DURING HIV-INFECTION - A LONGITUDINAL-STUDY
MARKERS OF IMMUNE STIMULATION IN THE CEREBROSPINAL-FLUID DURING HIV-INFECTION - A LONGITUDINAL-STUDY
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DOI：
10.3109/00365549409011810
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发表时间：
1994-01-01
影响因子：
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通讯作者：
HAGBERG, L
中科院分区：
文献类型：
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作者：
GISSLEN, M;CHIODI, F;HAGBERG, L
免疫刺激标记物进行了研究，在76个连续的脑脊液（CSF）样本从19例HIV-1感染的患者，没有抗逆转录病毒治疗的观察期从22个月到6年。这些患者中的8例进一步随访了14份CSF样本，为期3-24个月的齐多夫定治疗。在HIV-1感染过程中，CSF新蝶呤和β 2-微球蛋白（β 2 M）的平均浓度从12.7 nmol/l增加到20.4 nmol/l（p
Markers of immune stimulation were studied in 76 sequential cerebrospinal fluid (CSF) samples from 19 patients infected with HIV-1 without antiretroviral treatment during observation periods ranging from 22 months to 6 years. Eight of these patients were further followed with 14 CSF samples for 3-24 months of zidovudine treatment. During the course of HIV-1 infection, the mean CSF neopterin and beta(2)-microglobulin (beta 2M) concentrations increased from 12.7 to 20.4 nmol/l (p