Gene for autosomal dominant late-onset progressive non-syndromic hearing loss, DFNA10, maps to chromosome 6
Gene for autosomal dominant late-onset progressive non-syndromic hearing loss, DFNA10, maps to chromosome 6
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DOI：
10.1093/hmg/5.6.853
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发表时间：
1996-06-01
影响因子：
3.5
通讯作者：
Smith, RJH
中科院分区：
文献类型：
--
作者：
ONeill, ME;Marietta, J;Smith, RJH
迟发性非综合征性听力障碍是老年人最常见的神经功能障碍类型。它可以是后天获得的或遗传的，尽管遗传对这种类型的损失的相对影响尚不清楚。到目前为止，已经定位了9个不同的基因，但没有一个被克隆。利用一个常染色体显性迟发性非综合征性听力障碍基因分离的美国大家庭，我们在6号染色体上发现了一个新的基因座DFNA 10。
Late-onset non-syndromic hearing impairment is the most common type of neurological dysfunction in the elderly. It can be either acquired or inherited, although the relative impact of heredity on this type of loss is not known. To date, nine different genes have been localized, but none has been cloned. Using an extended American family in which a gene for autosomal dominant late-onset non-syndromic hearing impairment is segregating, we have identified a new locus, DFNA10, on chromosome 6.