Epidemiology of Peripheral Artery Disease
Epidemiology of Peripheral Artery Disease
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DOI：
10.1161/circresaha.116.303849
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发表时间：
2015-04-24
影响因子：
20.1
通讯作者：
Aboyans, Victor
中科院分区：
文献类型：
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作者：
Criqui, Michael H.;Aboyans, Victor
有关外周动脉疾病(PAD)流行病学的新数据已经可用，它们应该与以前的数据相结合。我们对PAD的流行病学进行了最新的、综合的概述，并对PAD的流行病学进行了重点文献综述。PAD结果被归类为美国和全球的症状、诊断、流行率和发病率、危险因素、进展、与其他动脉粥样硬化性疾病的共患率以及与心血管发病率和死亡率的相关性。PAD最常见的症状是间歇性跛行，但非侵入性测量，如踝臂指数，显示无症状PAD在人群中的发生率是间歇性跛行的几倍。PAD的患病率和发病率都与年龄密切相关，在60岁和70多岁的患者中上升了10%。随着全球人口老龄化，PAD似乎将在未来变得越来越常见。更严重或更有症状的疾病，男性的患病率似乎高于女性。PAD的主要危险因素与心脑血管疾病的主要危险因素相似，但因素的相对重要性有所不同。吸烟是PAD的一个特别强烈的危险因素，糖尿病也是如此，几个新的危险标记物已经显示出与PAD独立相关。PAD与伴发的心脑血管疾病密切相关。在调整了已知的心血管疾病危险因素后，PAD与冠状动脉和脑血管疾病发病率和死亡率的风险增加相关。
New data on the epidemiology of peripheral artery disease ( PAD) are available, and they should be integrated with previous data. We provide an updated, integrated overview of the epidemiology of PAD, a focused literature review was conducted on the epidemiology of PAD. The PAD results were grouped into symptoms, diagnosis, prevalence, and incidence both in the United States and globally, risk factors, progression, coprevalence with other atherosclerotic disease, and association with incident cardiovascular morbidity and mortality. The most common symptom of PAD is intermittent claudication, but noninvasive measures, such as the ankle-brachial index, show that asymptomatic PAD is several times more common in the population than intermittent claudication. PAD prevalence and incidence are both sharply age-related, rising >10% among patients in their 60s and 70s. With aging of the global population, it seems likely that PAD will be increasingly common in the future. Prevalence seems to be higher among men than women for more severe or symptomatic disease. The major risk factors for PAD are similar to those for coronary and cerebrovascular disease, with some differences in the relative importance of factors. Smoking is a particularly strong risk factor for PAD, as is diabetes mellitus, and several newer risk markers have shown independent associations with PAD. PAD is strongly associated with concomitant coronary and cerebrovascular diseases. After adjustment for known cardiovascular disease risk factors, PAD is associated with an increased risk of incident coronary and cerebrovascular disease morbidity and mortality.