Population-Level Patterns of Prostate Cancer Occurrence: Disparities in Virginia.
Population-Level Patterns of Prostate Cancer Occurrence: Disparities in Virginia.
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DOI：
10.1007/s40610-022-00147-w
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发表时间：
2022-03
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影响因子：
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通讯作者：
Lewallen, Eric A
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作者：
Adebola, Tunde M;Fennell, Herman W W;Druitt, Michael D;Bonin, Carolina A;Jenifer, Victoria A;van Wijnen, Andre J;Lewallen, Eric A
前列腺癌是最常见的癌症，也是美国男性癌症相关死亡的第二大原因。在弗吉尼亚州，这是一个代表性的，种族多元化的国家，超过800万人，成立近400年前，前列腺癌有最高的新发现率为任何类型的癌症。无论人口统计学如何，所有男性都有患前列腺癌的风险，但一些男性由于癌症转移而死亡风险增加。值得注意的是，五分之一的非洲裔美国男性在其一生中将被诊断出患有前列腺癌，他们在美国任何种族中的前列腺癌死亡率最高，包括弗吉尼亚州。一个人的遗传特征和家族史是前列腺癌风险的重要生物学决定因素，但可改变的环境因素（例如，污染）似乎与疾病流行和风险的模式有关。在这篇综述中，我们研究目前的观点在弗吉尼亚州的前列腺癌的人口水平的空间格局。为背景，最近，从疾病控制和预防中心公开可用的数据突出显示，并在空间格式。此外，我们探讨了前列腺癌的可能合并症，这些合并症可能在最近的健康差异研究中突出显示了人口统计学基础。
Prostate cancer is the most common cancer and the second leading cause of cancer-related deaths among men in the United States. In Virginia, which is a representative, ethnically diverse state of more than 8 million people that was established nearly 400 years ago, prostate cancer has the highest rate of new detection for any type of cancer. All men are at risk of developing prostate cancer regardless of demographics, but some men have an increased mortality risk due to cancer metastasis. Notably, one in five African American men will be diagnosed with prostate cancer in their lifetime and they have the highest prostate cancer mortality rate of any ethnic group in the United States, including Virginia. A person’s genetic profile and family history are important biological determinants of prostate cancer risk, but modifiable environmental factors (e.g., pollution) appear to be correlated with patterns of disease prevalence and risk. In this review, we examine current perspectives on population-level spatial patterns of prostate cancer in Virginia. For context, recent, publicly available data from the Centers for Disease Control and Prevention are highlighted and presented in spatial format. In addition, we explore possible co-morbidities of prostate cancer that may have demographic underpinnings highlighted in recent health disparity studies.