The insular cortex controls food preferences independently of taste receptor signaling.
The insular cortex controls food preferences independently of taste receptor signaling.
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DOI：
10.3389/fnsys.2012.00005
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发表时间：
2012
影响因子：
3
通讯作者：
Nicolelis MA
中科院分区：
文献类型：
--
作者：
Oliveira-Maia AJ;de Araujo IE;Monteiro C;Workman V;Galhardo V;Nicolelis MA
岛叶皮层（IC）包含口腔化学感觉（包括味觉）的初级感觉皮层，其完整性是适当控制摄食行为所必需的。然而，这一大脑区域在食物选择中的作用是否依赖于周边味觉输入仍然未知。通过多电极记录，我们发现自由舔食、甜盲的Trpm5 - / -小鼠IC中神经元群的反应受到蔗糖摄食后奖励效应的调节。FOS免疫反应性分析显示这些反应仅限于脑岛背侧。此外，该区域的双侧病变消除了这些Trpm5−/−动物对蔗糖的味觉独立偏好，同时保留了它们检测蔗糖的能力。总的来说，这些发现表明，即使在没有外围味觉输入的情况下，IC也会根据进食后的信号来调节食物的选择。
The insular cortex (IC) contains the primary sensory cortex for oral chemosensation including gustation, and its integrity is required for appropriate control of feeding behavior. However, it remains unknown whether the role of this brain area in food selection relies on the presence of peripheral taste input. Using multielectrode recordings, we found that the responses of populations of neurons in the IC of freely licking, sweet-blind Trpm5−/− mice are modulated by the rewarding postingestive effects of sucrose. FOS immunoreactivity analyses revealed that these responses are restricted to the dorsal insula. Furthermore, bilateral lesions in this area abolished taste-independent preferences for sucrose that can be conditioned in these Trpm5−/− animals while preserving their ability to detect sucrose. Overall, these findings demonstrate that, even in the absence of peripheral taste input, IC regulates food choices based on postingestive signals.